General Information:

Id: 9,274 (click here to show other Interactions for entry)
Diseases: Gastrointestinal
Major depressive disorder - [OMIM]
Metabolic
Neurological
Mammalia
review
Reference: Evrensel A and Ceylan ME(2015) The Gut-Brain Axis: The Missing Link in Depression Clin Psychopharmacol Neurosci 13: 239-244 [PMID: 26598580]

Interaction Information:

Comment Rat offspring separated from their mother caused a decrease in swimming in the forced swimming test and increased the immobility behavior, decreased norepinephrine levels in the brain, increased peripheral proinflammatory IL-6 secretion and corticotrophin-releasing factor mRNA levels in the amygdala. Probiotic therapy has led to a reversal of behavior problems and to the normalization of the immune response and norepinephrine levels in the brain.
Formal Description
Interaction-ID: 98845

process

response to psychosocial stress

decreases_quantity of

drug/chemical compound

Noradrenaline

in brain of rat offspring separated from their mother