General Information:

Id: 9,151 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Gastrointestinal
Metabolic
Mammalia
review
Reference: Hu X et al.(2016) Alzheimers disease and gut microbiota Sci China Life Sci 59: 1006-1023 [PMID: 27566465]

Interaction Information:

Comment Gram-positive Lactobacillus and Bifidobacterium in the gut, such as Lactobacillus brevis and Bifidobacterium dentium, are able to produce gamma-aminobutyric acid (GABA) by metabolizing glutamate. The increase of GABA in the gastrointestinal tract is correlated with the increase of GABA in CNS. Gut microbiota disruption, especially the reduction of Lactobacillus and Bifidobacterium, will influence the production of GABA in the gut and then lead to reduction of GABA in CNS.
Formal Description
Interaction-ID: 97991

environment

Bifidobacterium dentium

increases_quantity of

drug/chemical compound

GABA

in the gut; via metabolizing glutamate; gut microbiota disruption, especially the reduction of Lactobacillus and Bifidobacterium, will influence the production of GABA in the gut and then lead to reduction of GABA in CNS