General Information:

Id: 9,147 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Gastrointestinal
Mental
Metabolic
Neurological
Mammalia
review
Reference: de J R De-Paula V et al.(2018) Relevance of gutmicrobiota in cognition, behaviour and Alzheimers disease Pharmacol. Res. 136: 29-34 [PMID: 30138667]

Interaction Information:

Comment Lactobacilli and Bifidobacteria, components of the normal gut microbiota, convert monosodium glutamate into GABA; increased GABA in the gastrointestinal tract results in increased CNS availability of this neurotransmitter, up-regulating inhibitory signaling through GABAergic neurons.
Formal Description
Interaction-ID: 96548

environment

Bifidobacterium

increases_quantity of

drug/chemical compound

GABA

components of the normal gut microbiota; via converting monosodium glutamate into GABA