CIDeRplusGeneral Information:
| Id: | 9,077 (click here to show other Interactions for entry) |
| Diseases: |
Diabetes mellitus, type II
- [OMIM]
Insulin resistance |
| Mammalia | |
| review | |
| Reference: | Burnstock G(2014) Purinergic signalling in endocrine organs Purinergic Signal. 10: 189-231 [PMID: 24265070] |
Interaction Information:
| Comment | Insulin granules contain ATP (and ADP). These granules are secreted and were detected as quantal exocytotic release from rat beta-cells expressing P2X2 receptors acting as ATP biosensors; ATP concentrations up to 25 micromol/l close to plasma cell membranes have been detected. ATP was shown to be released by exocytosis, while insulin was retained in the granule, suggesting that basal release of ATP may have a role as an autocrine regulator. The vesicular nucleotide transporter (VNUT) is expressed in pancreatic beta-cells and VNUT-mediated ATP release is part of the mechanism that controls glucose-induced secretion. P2X receptors are critical in mediating the effect of ATP on insulin secretion when VNUT is overexpressed. Evidence has been presented to suggest that P2Y1 as well as P2X receptors play a role in the modulation of insulin secretion, proliferation and cell viability in mouse pancreatic beta-cells. ATP is also co-released with 5-hydroxythryptamine (5-HT), gamma-aminobutyric acid, glutamate and zinc, which have further autocrine coregulatory functions on insulin secretion. Extracellular nucleotides inhibit insulin receptor signalling. |
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Formal Description Interaction-ID: 95599 |
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