CIDeRplusGeneral Information:
| Id: | 8,447 (click here to show other Interactions for entry) |
| Diseases: |
Diabetes mellitus, type II
- [OMIM]
Insulin resistance Retinopathy, diabetic |
| Homo sapiens | |
| review | |
| Reference: | Liew G et al.(2017) Metabolomics of Diabetic Retinopathy Curr. Diab. Rep. 17: 102 [PMID: 28940103] |
Interaction Information:
| Comment | A study by Li et al. applied systems biology-based approaches to study metabolomics of blood plasma in patients with diabetic retinopathy. This study was novel as patients were classified according to usual Western (International) classification systems of diabetic retinopathy, as well as to a Chinese Medicine classification. The authors reported that in 88 patients with type 2 diabetes, the Western classification was associated with ten metabolites (pyruvic acids, L-aspartic acid, beta-hydroxybutyric acid, methylmalonic acid, citric acid, glucose, stearic acid, trans-oleic acid, linoleic acid, arachidonic acid), while the Chinese classification was associated with four metabolites (pyruvic acids, L-aspartic acid, glycerol, and cholesterol). Pyruvic acid and L-aspartic acid were identified in both classification systems. What was unclear in this study was the control group and whether they were free from diabetic retinopathy. The authors acknowledged another limitation as lack of data on the presence of chronic kidney disease, which could lead to impaired renal excretion of aspartic acid and other non-essential amino acids and result in the elevated levels observed in cases. |
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Formal Description Interaction-ID: 86252 |
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