General Information:

Id: 842 (click here to show other Interactions for entry)
Diseases: Parkinson disease
Drosophila melanogaster
transgenic Drosophila expressing either wild-type human LRRK2 or LRRK2-G2019S
BTO:0004032 dopaminergic neuron
article
Reference: Liu Z et al.(2008) A Drosophila model for LRRK2-linked parkinsonism Proc. Natl. Acad. Sci. U.S.A. 105: 2693-2698 [PMID: 18258746]

Interaction Information:

Comment Treatment of LRRK2-G2019S-2 flies (5 weeks of age) with 1 mM l-DOPA for 10 days significantly improved the locomotor activity, but did not prevent the loss of tyrosine hydroxylase-positive neurons.
Formal Description
Interaction-ID: 5048

drug/chemical compound

Dopamine

decreases_activity of

phenotype

abnormal locomotor behavior

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