General Information:

Id: 842
Diseases: Parkinson disease
Drosophila melanogaster
transgenic Drosophila expressing either wild-type human LRRK2 or LRRK2-G2019S
BTO:0004032 dopaminergic neuron
article
Reference: Liu Z et al.(2008) A Drosophila model for LRRK2-linked parkinsonism Proc. Natl. Acad. Sci. U.S.A. 105: 2693-2698 [PMID: 18258746]

Interaction Information:

Comment Expression of LRRK2 or LRRK2 mutant G2019S causes early mortality and locomotion impairment. G2019S-2-expressing flies displayed more severe impairment.
Formal Description
Interaction-ID: 4993

gene/protein

LRRK2

increases_activity of

phenotype

mortality

if LRRK2 is overexpressed
Comment Expression of LRRK2 or LRRK2 mutant G2019S causes early mortality and locomotion impairment. G2019S-2-expressing flies displayed more severe impairment.
Formal Description
Interaction-ID: 5044

gene/protein mutant

LRRK2-p.G2019S

increases_activity of

phenotype

mortality

Comment Expression of LRRK2 or LRRK2 mutant G2019S causes early mortality and locomotion impairment. G2019S-2-expressing flies displayed more severe impairment.
Formal Description
Interaction-ID: 5046

gene/protein

LRRK2

increases_activity of

phenotype

abnormal locomotor behavior

if LRRK2 is overexpressed
Comment Expression of LRRK2 or LRRK2 mutant G2019S causes early mortality and locomotion impairment. G2019S-2-expressing flies displayed more severe impairment.
Formal Description
Interaction-ID: 5047

gene/protein mutant

LRRK2-p.G2019S

increases_activity of

phenotype

abnormal locomotor behavior

Comment Treatment of LRRK2-G2019S-2 flies (5 weeks of age) with 1 mM l-DOPA for 10 days significantly improved the locomotor activity, but did not prevent the loss of tyrosine hydroxylase-positive neurons.
Formal Description
Interaction-ID: 5048

drug/chemical compound

Dopamine

decreases_activity of

phenotype

abnormal locomotor behavior

Drugbank entries Show/Hide entries for Dopamine
Comment LRRK2 or LRRK2-G2019S mutant, induces dopminergic neuronal degeneration.
Formal Description
Interaction-ID: 5050

gene/protein

LRRK2

increases_activity of

process

neuron death

if LRRK2 is overexpressed
Comment LRRK2 or LRRK2-G2019S mutant, induces dopminergic neuronal degeneration.
Formal Description
Interaction-ID: 5051

gene/protein mutant

LRRK2-p.G2019S

increases_activity of

process

neuron death

Comment Treatment of LRRK2-G2019S-2 flies (5 weeks of age) with 1 mM l-DOPA for 10 days significantly improved the locomotor activity, but did not prevent the loss of tyrosine hydroxylase-positive neurons.
Formal Description
Interaction-ID: 5053

drug/chemical compound

Dopamine

NOT decreases_activity of

process

neuron death

Drugbank entries Show/Hide entries for Dopamine