CIDeRplusGeneral Information:
| Id: | 8,380 (click here to show other Interactions for entry) |
| Diseases: |
Diabetes mellitus, type II
- [OMIM]
Fatty liver disease, nonalcoholic Insulin resistance |
| Homo sapiens | |
| article | |
| Reference: | Kalhan SC et al.(2011) Plasma metabolomic profile in nonalcoholic fatty liver disease Metab. Clin. Exp. 60: 404-413 [PMID: 20423748] |
Interaction Information:
| Comment | The plasma profile of subjects with nonalcoholic fatty liver disease (NAFLD), steatosis, and steatohepatitis (NASH) was examined using an untargeted global metabolomic analysis to identify specific disease-related patterns and to identify potential noninvasive biomarkers. Plasma samples were obtained after an overnight fast from histologically confirmed nondiabetic subjects with hepatic steatosis (n = 11) or NASH (n = 24) and were compared with healthy, age- and sex-matched controls (n = 25). Subjects with NAFLD were obese, were insulin resistant. Among the essential amino acids, phenylalanine and branched chain amino acids, leucine, isoleucine, and valine were higher in subjects with NASH as compared with controls. Glutamate, aspartate and tyrosine were also elevated in individuals with NASH. In contrast to subjects with NASH, only glutamate, lysine, tyrosine and isoleucine were significantly higher in subjects with steatosis compared with controls. There were no significant differences in amino acid levels amongst subjects with steatosis and NASH. |
|
Formal Description Interaction-ID: 85347 |
disease Steatohepatitis, nonalcoholic increases_quantity of drug/chemical compound |