CIDeRplusGeneral Information:
| Id: | 8,104 (click here to show other Interactions for entry) |
| Diseases: |
Diabetes mellitus, type II
- [OMIM]
Insulin resistance |
| Rattus norvegicus | |
| BTO:0003318 INS-1 823/13 cell | |
| article | |
| Reference: | Spegel P et al.(2013) Time-resolved metabolomics analysis of beta-cells implicates the pentose phosphate pathway in the control of insulin release Biochem. J. 450: 595-605 [PMID: 23282133] |
Interaction Information:
| Comment | Insulin secretion is coupled with changes in beta-cell metabolism. To define this process, 195 putative metabolites, mitochondrial respiration, NADP+, NADPH and insulin secretion were measured within 15 min of stimulation of clonal INS-1 832/13 beta-cells with glucose. Rapid responses in the major metabolic pathways of glucose occurred, involving several previously suggested metabolic coupling factors. The complex alterations in metabolite levels suggest that a coupling signal should reflect large parts of the beta-cell metabolic response. This was fulfilled by the NADPH/NADP+ ratio, which was elevated at 6 min after glucose stimulation. The NADPH/NADP+ ratio paralleled an increase in ribose 5-phosphate. |
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Formal Description Interaction-ID: 80976 |
decreases_quantity of drug/chemical compound |