CIDeRplusGeneral Information:
| Id: | 809 (click here to show other Interactions for entry) |
| Diseases: |
Alzheimer disease
- [OMIM]
Parkinson disease |
| Homo sapiens | |
| BTO:0000793 SH-SY5Y cell | |
| article | |
| Reference: | Uehara T et al.(2006) S-nitrosylated protein-disulphide isomerase links protein misfolding to neurodegeneration Nature 441: 513-517 [PMID: 16724068] |
Interaction Information:
| Comment | Initially, it was tested whether PDI could prevent the ubiquitinated, Lewy-body-like inclusions that are formed in the cytosol after synphilin-1 overexpression in cultured SH-SY5Y cells. When wild-type PDI was co-expressed with synphilin-1, discrete inclusions were greatly decreased, and instead ubiquitin-negative synphilin-1 was localized diffusely in the cytosol. NO attenuated the protective effect of PDI on synphilin-1 inclusions. These findings suggest that PDI is involved in protein folding linked to Parkinson disease in a NO-sensitive manner. |
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Formal Description Interaction-ID: 4659 |
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