CIDeRplusGeneral Information:
| Id: | 809 |
| Diseases: |
Alzheimer disease
- [OMIM]
Parkinson disease |
| Homo sapiens | |
| BTO:0000793 SH-SY5Y cell | |
| article | |
| Reference: | Uehara T et al.(2006) S-nitrosylated protein-disulphide isomerase links protein misfolding to neurodegeneration Nature 441: 513-517 [PMID: 16724068] |
Interaction Information:
| Comment | Initially, it was tested whether PDI could prevent the ubiquitinated, Lewy-body-like inclusions that are formed in the cytosol after synphilin-1 overexpression in cultured SH-SY5Y cells. When wild-type PDI was co-expressed with synphilin-1, discrete inclusions were greatly decreased, and instead ubiquitin-negative synphilin-1 was localized diffusely in the cytosol. NO attenuated the protective effect of PDI on synphilin-1 inclusions. These findings suggest that PDI is involved in protein folding linked to Parkinson disease in a NO-sensitive manner. |
|
Formal Description Interaction-ID: 4659 |
|
| Comment | Initially, it was tested whether PDI could prevent the ubiquitinated, Lewy-body-like inclusions that are formed in the cytosol after synphilin-1 overexpression in cultured SH-SY5Y cells. When wild-type PDI was co-expressed with synphilin-1, discrete inclusions were greatly decreased, and instead ubiquitin-negative synphilin-1 was localized diffusely in the cytosol. NO attenuated the protective effect of PDI on synphilin-1 inclusions. These findings suggest that PDI is involved in protein folding linked to Parkinson disease in a NO-sensitive manner. |
|
Formal Description Interaction-ID: 4660 |
|
| Comment | Cell death precipitated by thapsigargin and tunicamycin (to induce ER stress) or MG132 (to inhibit the proteasome) was largely abrogated by wild-type PDI. |
|
Formal Description Interaction-ID: 4674 |
|
| Comment | Cell death precipitated by thapsigargin and tunicamycin (to induce ER stress) or MG132 (to inhibit the proteasome) was largely abrogated by wild-type PDI. |
|
Formal Description Interaction-ID: 4675 |
|
| Comment | Cell death precipitated by thapsigargin and tunicamycin (to induce ER stress) or MG132 (to inhibit the proteasome) was largely abrogated by wild-type PDI. |
|
Formal Description Interaction-ID: 4676 |
|
| Comment | Cell death precipitated by thapsigargin and tunicamycin (to induce ER stress) or MG132 (to inhibit the proteasome) was largely abrogated by wild-type PDI. |
|
Formal Description Interaction-ID: 4677 |
gene/protein decreases_activity of |