CIDeRplusGeneral Information:
| Id: | 777 (click here to show other Interactions for entry) |
| Diseases: |
Amyotrophic lateral sclerosis
|
| Mus musculus | |
| SOD1G93A transgenic mouse, transfected with human SOD1G93A | |
| BTO:0001103 skeletal muscle | |
| article | |
| Reference: | Muller FL et al.(2007) Denervation-induced skeletal muscle atrophy is associated with increased mitochondrial ROS production Am. J. Physiol. Regul. Integr. Comp. Physiol. 293 [PMID: 17584954] |
Interaction Information:
| Comment | ROS production is increased in muscle mitochondria in mouse models of ALS and is correlated with the extent of muscle atrophy. State 1 ROS release during the disease course in G93A mice was increased almost 10-fold above levels in the mitochondria from wild-type mice, much higher than in the Sod1(-/-) mice or in old wild- type mice, which had relatively less muscle atrophy. |
|
Formal Description Interaction-ID: 4367 |
gene/protein mutant increases_quantity of drug/chemical compound Reactive oxygen species |