CIDeRplusGeneral Information:
| Id: | 777 |
| Diseases: |
Amyotrophic lateral sclerosis
|
| Mus musculus | |
| SOD1G93A transgenic mouse, transfected with human SOD1G93A | |
| BTO:0001103 skeletal muscle | |
| article | |
| Reference: | Muller FL et al.(2007) Denervation-induced skeletal muscle atrophy is associated with increased mitochondrial ROS production Am. J. Physiol. Regul. Integr. Comp. Physiol. 293 [PMID: 17584954] |
Interaction Information:
| Comment | ROS production is increased in muscle mitochondria in mouse models of ALS and is correlated with the extent of muscle atrophy. The decrease of muscle mass began as early as 60-70 days in the G93A mutants, even before visible symptoms occurred at the age of onset. Late-stage G93A mice exhibited decreases in hindlimb mass approaching 80%. |
|
Formal Description Interaction-ID: 4365 |
|
| Comment | ROS production is increased in muscle mitochondria in mouse models of ALS and is correlated with the extent of muscle atrophy. State 1 ROS release during the disease course in G93A mice was increased almost 10-fold above levels in the mitochondria from wild-type mice, much higher than in the Sod1(-/-) mice or in old wild- type mice, which had relatively less muscle atrophy. |
|
Formal Description Interaction-ID: 4367 |
gene/protein mutant increases_quantity of drug/chemical compound Reactive oxygen species |