CIDeRplusGeneral Information:
| Id: | 737 (click here to show other Interactions for entry) |
| Diseases: |
Parkinson disease
|
| Rattus norvegicus | |
| BTO:0001009 PC-12 cell | |
| article | |
| Reference: | Rodriguez-Blanco J et al.(2008) Intracellular signaling pathways involved in post-mitotic dopaminergic PC12 cell death induced by 6-hydroxydopamine. J. Neurochem. 107: 127-140 [PMID: 18665912] |
Interaction Information:
| Comment | Production of free radicals in the cells is significantly increased after 2h treatment with 6-OHDA. Besides the increase in intracellular oxidants, 6-OHDA also causes mitochondrial function impairment and DNA damage. Altogether, these events induce loss of mitochondrial potential, cytochrome c release and initiation of the apoptotic process. |
|
Formal Description Interaction-ID: 4127 |
drug/chemical compound 6-OHDA increases_quantity of drug/chemical compound Reactive oxygen species |