General Information:

Id: 682 (click here to show other Interactions for entry)
Diseases: Status epilepticus
Rattus norvegicus
Wistar
BTO:0000601 hippocampus; BTO:0001042 amygdala; BTO:0002785 rhinencephalon
article
Reference: Kuteykin-Teplyakov K et al.(2009) Complex time-dependent alterations in the brain expression of different drug efflux transporter genes after status epilepticus Epilepsia 50: 887-897 [PMID: 19055492]

Interaction Information:

Comment Between 6 and 24 h after onset of pilocarpine induced status epilepticus (SE), genes encoding Pgp (Mdr1a, Mdr1b), Mrp1, and Mrp5 were down-regulated in hippocampus, amygdala, or piriform cortex. This initial decrease in expression was followed by normalization and then increased expression, which became maximal 2 days after SE. One explanation for the initial decrease in transporter expression could be SE-induced acute inflammatory processes, because proinflammatory cytokines are known to suppress the expression of Pgp and other efflux transporters.
Formal Description
Interaction-ID: 3686

drug/chemical compound

Pilocarpine

affects_activity of

disease

Status epilepticus

Drugbank entries Show/Hide entries for Pilocarpine