Kuteykin-Teplyakov K et al.(2009) Complex time-dependent alterations in the brain expression of different drug efflux transporter genes after status epilepticus Epilepsia 50: 887-897
[PMID: 19055492]
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Between 6 and 24 h after onset of pilocarpine induced status epilepticus (SE),
genes encoding Pgp (Mdr1a, Mdr1b), Mrp1, and Mrp5 were down-regulated in hippocampus, amygdala, or piriform cortex. This initial decrease in expression was followed by normalization and then increased expression, which became maximal 2 days after SE. One explanation for the initial decrease in transporter expression could be SE-induced acute inflammatory processes, because proinflammatory cytokines are known to suppress the expression of Pgp and other
efflux transporters.
Between 6 and 24 h after onset of pilocarpine induced status epilepticus (SE),
genes encoding Pgp (Mdr1a, Mdr1b), Mrp1, and Mrp5 were down-regulated in hippocampus, amygdala, or piriform cortex. This initial decrease in expression was followed by normalization and then increased expression, which became maximal 2 days after SE. One explanation for the initial decrease in transporter expression could be SE-induced acute inflammatory processes, because pro-inflammatory cytokines are known to suppress the expression of Pgp and other
efflux transporters.
Between 6 and 24 h after onset of pilocarpine induced status epilepticus (SE),
genes encoding Pgp (Mdr1a, Mdr1b), Mrp1, and Mrp5 were down-regulated in hippocampus, amygdala, or piriform cortex. This initial decrease in expression was followed by normalization and then increased expression, which became maximal 2 days after SE. One explanation for the initial decrease in transporter expression could be SE-induced acute inflammatory processes, because pro-inflammatory cytokines are known to suppress the expression of Pgp and other
efflux transporters.
Between 6 and 24 h after onset of pilocarpine induced status epilepticus (SE),
genes encoding Pgp (Mdr1a, Mdr1b), Mrp1, and Mrp5 were down-regulated in hippocampus, amygdala, or piriform cortex. This initial decrease in expression was followed by normalization and then increased expression, which became maximal 2 days after SE. One explanation for the initial decrease in transporter expression could be SE-induced acute inflammatory processes, because proinflammatory cytokines are known to suppress the expression of Pgp and other
efflux transporters.
Between 6 and 24 h after onset of pilocarpine induced status epilepticus (SE),
genes encoding Pgp (Mdr1a, Mdr1b), Mrp1, and Mrp5 were down-regulated in hippocampus, amygdala, or piriform cortex. This initial decrease in expression was followed by normalization and then increased expression, which became maximal 2 days after SE. One explanation for the initial decrease in transporter expression could be SE-induced acute inflammatory processes, because pro-inflammatory cytokines are known to suppress the expression of Pgp and other
efflux transporters.
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