CIDeRplusGeneral Information:
| Id: | 6,326 (click here to show other Interactions for entry) |
| Diseases: |
Diabetes mellitus, type II
- [OMIM]
Insulin resistance |
| Mus musculus | |
| article | |
| Reference: | Li Q et al.(2013) Activation of Akt through 5-HT2A receptor ameliorates serotonin-induced degradation of insulin receptor substrate-1 in adipocytes Mol. Cell. Endocrinol. 365: 25-35 [PMID: 22975078] |
Interaction Information:
| Comment | This study demonstrated that chronic exposure of adipocytes to the elevated levels of serotonin (5-hydroxytryptamine, 5-HT) causes IRS-1 serine phosphorylation, cytosolic translocation and degradation, leading to the attenuation of insulin signaling in adipocytes. |
|
Formal Description Interaction-ID: 59388 |
drug/chemical compound decreases_activity of |