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Field	Query

	Field	Term

General Information:

Id:	6,326
Diseases:	Diabetes mellitus, type II - [OMIM] Insulin resistance
Organism:	Mus musculus
Publication type:	article
Reference:	Li Q et al.(2013) Activation of Akt through 5-HT2A receptor ameliorates serotonin-induced degradation of insulin receptor substrate-1 in adipocytes Mol. Cell. Endocrinol. 365: 25-35 [PMID: 22975078]

Interaction Information:

Comment	Serotonin (5-hydroxytryptamine, 5-HT) was found to be elevated in the serum of diabetic patients. In 3T3-L1 adipocytes, 5-HT treatment induced the translocation of insulin receptor substrate-1 (IRS-1) from low density microsome (LDM), the important intracellular compartment for its functions, to cytosol, inducing IRS-1 ubiquitination and degradation.
Formal Description Interaction-ID: 59383	drug/chemical compound Serotonin decreases_quantity of gene/protein IRS1 in 3T3-L1 adipocytes
Drugbank entries	Show/Hide entries for IRS1
Drugbank DB08513	[4-({5-(AMINOCARBONYL)-4-[(3-METHYLPHENY ... not specified IRS1

Comment	The study investigated the effects of serotonin (5-hydroxytryptamine, 5-HT) on insulin signal transduction involved in glucose uptake. 5-HT-treatment decreased insulin-stimulated Akt phosphorylation and glucose uptake through the induction of IRS-1 degradation.
Formal Description Interaction-ID: 59384	drug/chemical compound Serotonin decreases_phosphorylation of gene/protein AKT1 in 3T3-L1 adipocytes
Drugbank entries	Show/Hide entries for AKT1
Drugbank DB00171	Adenosine triphosphate not specified AKT1
Drugbank DB01169	Arsenic trioxide inducer AKT1
Drugbank DB01863	Inositol 1,3,4,5-Tetrakisphosphate not specified AKT1
Drugbank DB07584	N-[2-(5-methyl-4H-1,2,4-triazol-3-yl)phe ... not specified AKT1
Drugbank DB07585	5-(5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4 ... not specified AKT1
Drugbank DB00171	Adenosine triphosphate not specified AKT1
Drugbank DB01863	Inositol 1,3,4,5-Tetrakisphosphate not specified AKT1

Comment	The study investigated the effects of serotonin (5-hydroxytryptamine, 5-HT) on insulin signal transduction involved in glucose uptake. 5-HT-treatment decreased insulin-stimulated Akt phosphorylation and glucose uptake through the induction of IRS-1 degradation.
Formal Description Interaction-ID: 59385	drug/chemical compound Serotonin decreases_activity of process glucose import in 3T3-L1 adipocytes

Comment	Serotonin (5-hydroxytryptamine, 5-HT) down-regulated the insulin-stimulated tyrosine phosphorylation of IRS-1 and the docking of p85 regulatory subunit of PI3K.
Formal Description Interaction-ID: 59386	drug/chemical compound Serotonin decreases_phosphorylation of gene/protein IRS1 in 3T3-L1 adipocytes; at tyrosine residues
Drugbank entries	Show/Hide entries for IRS1
Drugbank DB08513	[4-({5-(AMINOCARBONYL)-4-[(3-METHYLPHENY ... not specified IRS1

Comment	Serotonin (5-hydroxytryptamine, 5-HT) down-regulated the insulin-stimulated tyrosine phosphorylation of IRS-1 and the docking of p85 regulatory subunit of PI3K.
Formal Description Interaction-ID: 59387	drug/chemical compound Serotonin decreases_quantity of complex/PPI PIK3R1-IRS1 complex in 3T3-L1 adipocytes

Comment	This study demonstrated that chronic exposure of adipocytes to the elevated levels of serotonin (5-hydroxytryptamine, 5-HT) causes IRS-1 serine phosphorylation, cytosolic translocation and degradation, leading to the attenuation of insulin signaling in adipocytes.
Formal Description Interaction-ID: 59388	drug/chemical compound Serotonin decreases_activity of process insulin receptor signaling pathway in 3T3-L1 adipocytes

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