General Information:

Id: 6,326 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mus musculus
article
Reference: Li Q et al.(2013) Activation of Akt through 5-HT2A receptor ameliorates serotonin-induced degradation of insulin receptor substrate-1 in adipocytes Mol. Cell. Endocrinol. 365: 25-35 [PMID: 22975078]

Interaction Information:

Comment Serotonin (5-hydroxytryptamine, 5-HT) down-regulated the insulin-stimulated tyrosine phosphorylation of IRS-1 and the docking of p85 regulatory subunit of PI3K.
Formal Description
Interaction-ID: 59387

drug/chemical compound

Serotonin

decreases_quantity of

complex/PPI

PIK3R1-IRS1 complex

in 3T3-L1 adipocytes