CIDeRplusGeneral Information:
| Id: | 6,326 (click here to show other Interactions for entry) |
| Diseases: |
Diabetes mellitus, type II
- [OMIM]
Insulin resistance |
| Mus musculus | |
| article | |
| Reference: | Li Q et al.(2013) Activation of Akt through 5-HT2A receptor ameliorates serotonin-induced degradation of insulin receptor substrate-1 in adipocytes Mol. Cell. Endocrinol. 365: 25-35 [PMID: 22975078] |
Interaction Information:
| Comment | Serotonin (5-hydroxytryptamine, 5-HT) was found to be elevated in the serum of diabetic patients. In 3T3-L1 adipocytes, 5-HT treatment induced the translocation of insulin receptor substrate-1 (IRS-1) from low density microsome (LDM), the important intracellular compartment for its functions, to cytosol, inducing IRS-1 ubiquitination and degradation. |
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Formal Description Interaction-ID: 59383 |
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| Drugbank entries | Show/Hide entries for IRS1 |