CIDeRplusGeneral Information:
| Id: | 6,307 (click here to show other Interactions for entry) |
| Diseases: |
Cancer
Diabetes mellitus, type II - [OMIM] Insulin resistance |
| Mammalia | |
| article | |
| Reference: | Tanaka T et al.(2014) Neuroendocrine signaling via the serotonin transporter regulates clearance of apoptotic cells J. Biol. Chem. 289 [PMID: 24570000] |
Interaction Information:
| Comment | Serotonin (5-hydroxytryptamine; 5-HT) impaired efferocytosis by murine peritoneal macrophages and human alveolar macrophages. 5-HT increased phosphorylation of myosin phosphatase subunit 1 (Mypt-1) at Thr-696, a known ROCK target, and inhibitors of RhoA and ROCK reversed the suppressive effect of 5-HT on efferocytosis. |
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Formal Description Interaction-ID: 59071 |
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