CIDeRplusGeneral Information:
| Id: | 6,307 |
| Diseases: |
Cancer
Diabetes mellitus, type II - [OMIM] Insulin resistance |
| Mammalia | |
| article | |
| Reference: | Tanaka T et al.(2014) Neuroendocrine signaling via the serotonin transporter regulates clearance of apoptotic cells J. Biol. Chem. 289 [PMID: 24570000] |
Interaction Information:
| Comment | Serotonin (5-hydroxytryptamine; 5-HT) impaired efferocytosis by murine peritoneal macrophages and human alveolar macrophages. 5-HT increased phosphorylation of myosin phosphatase subunit 1 (Mypt-1), a known ROCK target, and inhibitors of RhoA and ROCK reversed the suppressive effect of 5-HT on efferocytosis. |
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Formal Description Interaction-ID: 59063 |
drug/chemical compound decreases_activity of process |
| Comment | Serotonin (5-hydroxytryptamine; 5-HT) impaired efferocytosis by murine peritoneal macrophages and human alveolar macrophages. 5-HT increased phosphorylation of myosin phosphatase subunit 1 (Mypt-1) at Thr-696, a known ROCK target, and inhibitors of RhoA and ROCK reversed the suppressive effect of 5-HT on efferocytosis. |
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Formal Description Interaction-ID: 59066 |
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| Comment | Peritoneal macrophages expressed the 5-HT (serotonin) transporter and 5-HT receptors (R) 2a, 2b, but not 2c. |
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Formal Description Interaction-ID: 59067 |
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| Drugbank entries | Show/Hide entries for SLC6A4 |
| Comment | Peritoneal macrophages expressed the 5-HT (serotonin) transporter and 5-HT receptors (R) 2a, 2b, but not 2c. |
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Formal Description Interaction-ID: 59068 |
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| Drugbank entries | Show/Hide entries for HTR2A |
| Comment | Peritoneal macrophages expressed the 5-HT (serotonin) transporter and 5-HT receptors (R) 2a, 2b, but not 2c. |
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Formal Description Interaction-ID: 59069 |
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| Drugbank entries | Show/Hide entries for HTR2B |
| Comment | Peritoneal macrophages expressed the 5-HT (serotonin) transporter and 5-HT receptors (R) 2a, 2b, but not 2c. |
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Formal Description Interaction-ID: 59070 |
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| Drugbank entries | Show/Hide entries for HTR2C |
| Comment | Serotonin (5-hydroxytryptamine; 5-HT) impaired efferocytosis by murine peritoneal macrophages and human alveolar macrophages. 5-HT increased phosphorylation of myosin phosphatase subunit 1 (Mypt-1) at Thr-696, a known ROCK target, and inhibitors of RhoA and ROCK reversed the suppressive effect of 5-HT on efferocytosis. |
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Formal Description Interaction-ID: 59071 |
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| Comment | Inhibition of 5-HTR2a and 5-HTR2b had no effect on efferocytosis, but blockade of the 5-HT transporter prevented 5-HT-impaired efferocytosis. Genetic deletion of the 5-HT transporter inhibited 5-HT uptake into peritoneal macrophages, prevented 5-HT-induced phosphorylation of Mypt-1, reversed the inhibitory effect of 5-HT on efferocytosis, and decreased cellular peritoneal inflammation. |
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Formal Description Interaction-ID: 59072 |
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| Drugbank entries | Show/Hide entries for HTR2A |
| Comment | Inhibition of 5-HTR2a and 5-HTR2b had no effect on efferocytosis, but blockade of the 5-HT transporter prevented 5-HT-impaired efferocytosis. Genetic deletion of the 5-HT transporter inhibited 5-HT uptake into peritoneal macrophages, prevented 5-HT-induced phosphorylation of Mypt-1, reversed the inhibitory effect of 5-HT on efferocytosis, and decreased cellular peritoneal inflammation. |
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Formal Description Interaction-ID: 59073 |
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| Drugbank entries | Show/Hide entries for HTR2B |
| Comment | Inhibition of 5-HTR2a and 5-HTR2b had no effect on efferocytosis, but blockade of the 5-HT transporter prevented 5-HT-impaired efferocytosis. Genetic deletion of the 5-HT transporter inhibited 5-HT uptake into peritoneal macrophages, prevented 5-HT-induced phosphorylation of Mypt-1, reversed the inhibitory effect of 5-HT on efferocytosis, and decreased cellular peritoneal inflammation. |
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Formal Description Interaction-ID: 59074 |
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| Drugbank entries | Show/Hide entries for SLC6A4 |
| Comment | Inhibition of 5-HTR2a and 5-HTR2b had no effect on efferocytosis, but blockade of the 5-HT transporter prevented 5-HT-impaired efferocytosis. Genetic deletion of the 5-HT transporter inhibited 5-HT uptake into peritoneal macrophages, prevented 5-HT-induced phosphorylation of Mypt-1, reversed the inhibitory effect of 5-HT on efferocytosis, and decreased cellular peritoneal inflammation. |
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Formal Description Interaction-ID: 59075 |
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| Drugbank entries | Show/Hide entries for SLC6A4 |
| Comment | Inhibition of 5-HTR2a and 5-HTR2b had no effect on efferocytosis, but blockade of the 5-HT transporter prevented 5-HT-impaired efferocytosis. Genetic deletion of the 5-HT transporter inhibited 5-HT uptake into peritoneal macrophages, prevented 5-HT-induced phosphorylation of Mypt-1, reversed the inhibitory effect of 5-HT on efferocytosis, and decreased cellular peritoneal inflammation. |
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Formal Description Interaction-ID: 59076 |
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| Drugbank entries | Show/Hide entries for SLC6A4 |