General Information:

Id: 6,307 (click here to show other Interactions for entry)
Diseases: Cancer
Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mammalia
article
Reference: Tanaka T et al.(2014) Neuroendocrine signaling via the serotonin transporter regulates clearance of apoptotic cells J. Biol. Chem. 289 [PMID: 24570000]

Interaction Information:

Comment Serotonin (5-hydroxytryptamine; 5-HT) impaired efferocytosis by murine peritoneal macrophages and human alveolar macrophages. 5-HT increased phosphorylation of myosin phosphatase subunit 1 (Mypt-1), a known ROCK target, and inhibitors of RhoA and ROCK reversed the suppressive effect of 5-HT on efferocytosis.
Formal Description
Interaction-ID: 59063

drug/chemical compound

Serotonin

decreases_activity of

process

apoptotic cell clearance

via RHOA and ROCK