CIDeRplusGeneral Information:
| Id: | 6,151 (click here to show other Interactions for entry) |
| Diseases: |
Diabetes mellitus, type II
- [OMIM]
Insulin resistance |
| Mus musculus | |
| article | |
| Reference: | Raddatz K et al.(2012) Deletion of protein kinase Cepsilon in mice has limited effects on liver metabolite levels but alters fasting ketogenesis and gluconeogenesis Diabetologia 55: 2789-2793 [PMID: 22814763] |
Interaction Information:
| Comment | Protein kinase C epsilon (PKCepsilon) is emerging as a key mediator of lipid-induced insulin resistance in liver and hepatic lipid metabolism itself. The levels of 20 compounds were altered similarly in livers from both WT and Prkce-/- high-fat-fed mice, indicating a consistent response to the high-fat diet. Alanine, ethanolamine and gamma-aminobutyric acid levels were reduced by approximately 50% by fat feeding, while tocopherol, sucrose and taurine levels were significantly increased. Prkce deletion resulted only in a reduction of 4-hydroxyproline and aspartate and an increase in glutamate. |
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Formal Description Interaction-ID: 57564 |
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