General Information:

Id: 581 (click here to show other Interactions for entry)
Diseases: Amyotrophic lateral sclerosis
Rattus norvegicus
BTO:0004102 cerebral cortical neuron
article
Reference: Ackerley S et al.(2000) Glutamate slows axonal transport of neurofilaments in transfected neurons. J. Cell Biol. 150: 165-176 [PMID: 10893265]

Interaction Information:

Comment Glutamate activates members of the MAP kinase family including p42/p44MAPK and SAPK1b, neurofilament side-arm domains are substrates for these kinases, and glutamate induces increased phosphorylation of neurofilament side-arms in cell bodies of cortical neurons.
Formal Description
Interaction-ID: 3066

drug/chemical compound

Glutamate

increases_activity of

gene/protein

MAPK1

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