General Information:

Id: 581
Diseases: Amyotrophic lateral sclerosis
Rattus norvegicus
BTO:0004102 cerebral cortical neuron
article
Reference: Ackerley S et al.(2000) Glutamate slows axonal transport of neurofilaments in transfected neurons. J. Cell Biol. 150: 165-176 [PMID: 10893265]

Interaction Information:

Comment Glutamate retards anterograde transport of EGFP-NF-M (enhanced green fluorescent protein-tagged neurofilament-M) in cultured cortical neurons without affecting cell viability or neurofilament protein levels, and this effect is mediated at least, in part, through NMDA-type glutamate receptors.
Formal Description
Interaction-ID: 3063

drug/chemical compound

Glutamate

decreases_activity of

process

anterograde axon cargo transport

in cortical neurons
Comment Glutamate retards anterograde transport of EGFP-NF-M (enhanced green fluorescent protein-tagged neurofilament-M) in cultured cortical neurons without affecting cell viability or neurofilament protein levels, and this effect is mediated at least, in part, through NMDA-type glutamate receptors.
Formal Description
Interaction-ID: 3065

drug/chemical compound

Glutamate

decreases transport of

gene/protein

NEFM

in cortical neurons
Comment Glutamate activates members of the MAP kinase family including p42/p44MAPK and SAPK1b, neurofilament side-arm domains are substrates for these kinases, and glutamate induces increased phosphorylation of neurofilament side-arms in cell bodies of cortical neurons.
Formal Description
Interaction-ID: 3066

drug/chemical compound

Glutamate

increases_activity of

gene/protein

MAPK1

Drugbank entries Show/Hide entries for MAPK1
Comment Glutamate activates members of the MAP kinase family including p42/p44MAPK and SAPK1b, neurofilament side-arm domains are substrates for these kinases, and glutamate induces increased phosphorylation of neurofilament side-arms in cell bodies of cortical neurons.
Formal Description
Interaction-ID: 3067

drug/chemical compound

Glutamate

increases_activity of

gene/protein

MAPK3

Drugbank entries Show/Hide entries for MAPK3
Comment Glutamate activates members of the MAP kinase family including p42/p44MAPK and SAPK1b, neurofilament side-arm domains are substrates for these kinases, and glutamate induces increased phosphorylation of neurofilament side-arms in cell bodies of cortical neurons.
Formal Description
Interaction-ID: 3068

drug/chemical compound

Glutamate

increases_activity of

gene/protein

MAPK10

Drugbank entries Show/Hide entries for MAPK10
Comment Glutamate activates members of the MAP kinase family including p42/p44MAPK and SAPK1b, neurofilament side-arm domains are substrates for these kinases, and glutamate induces increased phosphorylation of neurofilament side-arms in cell bodies of cortical neurons. Both NF-M and NF-H substrates, but not GST, were phosphorylated by p42MAPK and SAPK1b.
Formal Description
Interaction-ID: 3069

gene/protein

MAPK1

increases_phosphorylation of

gene/protein

NEFM

in cell bodies of cortical neurons; induced by glutamate
Drugbank entries Show/Hide entries for MAPK1
Comment Glutamate activates members of the MAP kinase family including p42/p44MAPK and SAPK1b, neurofilament side-arm domains are substrates for these kinases, and glutamate induces increased phosphorylation of neurofilament side-arms in cell bodies of cortical neurons. Both NF-M and NF-H substrates, but not GST, were phosphorylated by p42MAPK and SAPK1b.
Formal Description
Interaction-ID: 3070

gene/protein

MAPK1

increases_phosphorylation of

gene/protein

NEFH

in cell bodies of cortical neurons; induced by glutamate
Drugbank entries Show/Hide entries for MAPK1
Comment Glutamate activates members of the MAP kinase family including p42/p44MAPK and SAPK1b, neurofilament side-arm domains are substrates for these kinases, and glutamate induces increased phosphorylation of neurofilament side-arms in cell bodies of cortical neurons. Both NF-M and NF-H substrates, but not GST, were phosphorylated by p42MAPK and SAPK1b.
Formal Description
Interaction-ID: 3071

gene/protein

MAPK10

increases_phosphorylation of

gene/protein

NEFM

in cell bodies of cortical neurons; induced by glutamate
Drugbank entries Show/Hide entries for MAPK10
Comment Glutamate activates members of the MAP kinase family including p42/p44MAPK and SAPK1b, neurofilament side-arm domains are substrates for these kinases, and glutamate induces increased phosphorylation of neurofilament side-arms in cell bodies of cortical neurons. Both NF-M and NF-H substrates, but not GST, were phosphorylated by p42MAPK and SAPK1b.
Formal Description
Interaction-ID: 3073

gene/protein

MAPK10

increases_phosphorylation of

gene/protein

NEFH

in cell bodies of cortical neurons; induced by glutamate
Drugbank entries Show/Hide entries for MAPK10
Comment Glutamate activates members of the MAP kinase family including p42/p44MAPK and SAPK1b, neurofilament side-arm domains are substrates for these kinases, and glutamate induces increased phosphorylation of neurofilament side-arms in cell bodies of cortical neurons. Both NF-M and NF-H substrates, but not GST, were phosphorylated by p42MAPK and SAPK1b.
Formal Description
Interaction-ID: 13756

gene/protein

MAPK1

increases_quantity of

protein modification

NEFM-mod

in cell bodies of cortical neurons; induced by glutamate
Drugbank entries Show/Hide entries for MAPK1
Comment Glutamate activates members of the MAP kinase family including p42/p44MAPK and SAPK1b, neurofilament side-arm domains are substrates for these kinases, and glutamate induces increased phosphorylation of neurofilament side-arms in cell bodies of cortical neurons. Both NF-M and NF-H substrates, but not GST, were phosphorylated by p42MAPK and SAPK1b.
Formal Description
Interaction-ID: 13757

gene/protein

MAPK1

increases_quantity of

protein modification

NEFH-mod

in cell bodies of cortical neurons; induced by glutamate
Drugbank entries Show/Hide entries for MAPK1
Comment Glutamate activates members of the MAP kinase family including p42/p44MAPK and SAPK1b, neurofilament side-arm domains are substrates for these kinases, and glutamate induces increased phosphorylation of neurofilament side-arms in cell bodies of cortical neurons. Both NF-M and NF-H substrates, but not GST, were phosphorylated by p42MAPK and SAPK1b.
Formal Description
Interaction-ID: 13758

gene/protein

MAPK10

increases_quantity of

protein modification

NEFM-mod

in cell bodies of cortical neurons; induced by glutamate
Drugbank entries Show/Hide entries for MAPK10
Comment Glutamate activates members of the MAP kinase family including p42/p44MAPK and SAPK1b, neurofilament side-arm domains are substrates for these kinases, and glutamate induces increased phosphorylation of neurofilament side-arms in cell bodies of cortical neurons. Both NF-M and NF-H substrates, but not GST, were phosphorylated by p42MAPK and SAPK1b.
Formal Description
Interaction-ID: 13760

gene/protein

MAPK10

increases_quantity of

protein modification

NEFH-mod

in cell bodies of cortical neurons; induced by glutamate
Drugbank entries Show/Hide entries for MAPK10