General Information:

Id: 581 (click here to show other Interactions for entry)
Diseases: Amyotrophic lateral sclerosis
Rattus norvegicus
BTO:0004102 cerebral cortical neuron
article
Reference: Ackerley S et al.(2000) Glutamate slows axonal transport of neurofilaments in transfected neurons. J. Cell Biol. 150: 165-176 [PMID: 10893265]

Interaction Information:

Comment Glutamate retards anterograde transport of EGFP-NF-M (enhanced green fluorescent protein-tagged neurofilament-M) in cultured cortical neurons without affecting cell viability or neurofilament protein levels, and this effect is mediated at least, in part, through NMDA-type glutamate receptors.
Formal Description
Interaction-ID: 3063

drug/chemical compound

Glutamate

decreases_activity of

process

anterograde axon cargo transport

in cortical neurons