General Information:

Id: 555 (click here to show other Interactions for entry)
Diseases: Amyotrophic lateral sclerosis
Rattus norvegicus
BTO:0001264 spinal ganglion
article
Reference: Kesavapany S et al.(2007) Inhibition of Pin1 reduces glutamate-induced perikaryal accumulation of phosphorylated neurofilament-H in neurons. Mol. Biol. Cell 18: 3645-3655 [PMID: 17626162]

Interaction Information:

Comment Glutamate toxicity in DRG (dorsal root ganglion) neurons produces accumulations of p-NF-H (phosphorylated neurofilament H) and Pin1. Glutamate treatment, resulted in an approximate twofold increase in p-NF-H levels relative to untreated neurons.
Formal Description
Interaction-ID: 2863

drug/chemical compound

Glutamate

increases_quantity of

protein modification

NEFH-mod

in DRG neurons