CIDeRplusGeneral Information:
| Id: | 555 |
| Diseases: |
Amyotrophic lateral sclerosis
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| Rattus norvegicus | |
| BTO:0001264 spinal ganglion | |
| article | |
| Reference: | Kesavapany S et al.(2007) Inhibition of Pin1 reduces glutamate-induced perikaryal accumulation of phosphorylated neurofilament-H in neurons. Mol. Biol. Cell 18: 3645-3655 [PMID: 17626162] |
Interaction Information:
| Comment | Glutamate toxicity in DRG (dorsal root ganglion) neurons produces accumulations of p-NF-H (phosphorylated neurofilament H) and Pin1. Glutamate treatment, resulted in an approximate twofold increase in p-NF-H levels relative to untreated neurons. |
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Formal Description Interaction-ID: 2863 |
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| Comment | Glutamate treatment resulted in an increase in p-NF-H staining in the neuronal cell body without any change in Pin1 staining; the two proteins colocalized in this compartment. |
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Formal Description Interaction-ID: 2864 |
protein modification NEFH-mod interacts (colocalizes) with gene/protein |
| Drugbank entries | Show/Hide entries for PIN1 |
| Comment | The cell body accumulation of p-NF-H (phosphorylated neurofilament H) was reduced when neurons were incubated with juglone (Pin1 inhibitor) before glutamate exposure, colocalization of Pin1 and p-NF-H was also reduced. |
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Formal Description Interaction-ID: 2869 |
drug/chemical compound decreases_quantity of protein modification NEFH-mod |
| Comment | Glutamate-mediated increase in phosphorylated NF-H is reduced by dominant negative Pin1 and Pin1-siRNA transfection. |
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Formal Description Interaction-ID: 2881 |
gene/protein increases_quantity of protein modification NEFH-mod |
| Drugbank entries | Show/Hide entries for PIN1 |
| Comment | Neuronal death increased nearly four times upon exposure to glutamate, and this was reduced nearly twofold when neurons were treated with juglone before glutamate treatment. |
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Formal Description Interaction-ID: 2893 |
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| Comment | Neuronal death increased nearly four times upon exposure to glutamate, and this was reduced nearly twofold when neurons were treated with juglone (Pin1 inhibitor) before glutamate treatment. |
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Formal Description Interaction-ID: 2894 |
drug/chemical compound decreases_activity of process |
| Comment | Inhibition of Pin1 reduces glutamate mediated neuronal cell death. |
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Formal Description Interaction-ID: 2895 |
gene/protein increases_activity of process |
| Drugbank entries | Show/Hide entries for PIN1 |
| Comment | Juglone is a specific inhibitor of Pin1. |
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Formal Description Interaction-ID: 4114 |
drug/chemical compound decreases_activity of gene/protein |
| Drugbank entries | Show/Hide entries for PIN1 |