General Information:

Id: 5,409 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Rattus norvegicus
male
article
Reference: Sibilia V et al.(2013) Dietary tryptophan manipulation reveals a central role for serotonin in the anabolic response of appendicular skeleton to physical activity in rats Endocrine 44: 790-802 [PMID: 23619963]

Interaction Information:

Comment Since mechanical stimulation activates in osteoblasts the Wnt/beta-catenin pathway, the effects of serotonin (5-HT) on various elements of Wnt/beta-catenin pathway were examined. Beta-catenin protein was significantly increased 30 min after 5-HT exposure. 5-HT induced a significant increase in GSK-3beta phosphorylation compared to total GSK3-beta, indicating that 5-HT modulates beta-catenin protein levels by inhibiting GSK-3beta activation.
Formal Description
Interaction-ID: 52744

drug/chemical compound

Serotonin

increases_quantity of

gene/protein

CTNNB1

in osteoblasts
Drugbank entries Show/Hide entries for CTNNB1