CIDeRplusGeneral Information:
| Id: | 5,409 |
| Diseases: |
Diabetes mellitus, type II
- [OMIM]
Insulin resistance |
| Rattus norvegicus | |
| male | |
| article | |
| Reference: | Sibilia V et al.(2013) Dietary tryptophan manipulation reveals a central role for serotonin in the anabolic response of appendicular skeleton to physical activity in rats Endocrine 44: 790-802 [PMID: 23619963] |
Interaction Information:
| Comment | In tryptophan (TRP)-free diet-treated rats, mean body weight was significantly reduced compared with baseline and with control-diet-treated rats starting from 35 days. TRP-supplement diet resulted in an increase in body weight which did not reach statistical significance as compared with TRP-free diet-treated rats. |
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Formal Description Interaction-ID: 52732 |
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| Comment | Tryptophan (TRP)-free diet significantly reduced the 24-h urinary excretion of 5-hydroxyindoleacetic acid (5-HIAA) compared with control-diet-treated rats at both times of testing. TRP-supplemented diet resulted in a significant increase of 5-HIAA. |
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Formal Description Interaction-ID: 52742 |
environment tryptophan-free diet decreases_quantity of drug/chemical compound |
| Comment | Tryptophan (TRP)-free diet significantly worsened bone loss consequent to decreased physical activity at all the skeletal sites examined. |
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Formal Description Interaction-ID: 52743 |
environment tryptophan-free diet increases_activity of phenotype |
| Comment | Since mechanical stimulation activates in osteoblasts the Wnt/beta-catenin pathway, the effects of serotonin (5-HT) on various elements of Wnt/beta-catenin pathway were examined. Beta-catenin protein was significantly increased 30 min after 5-HT exposure. 5-HT induced a significant increase in GSK-3beta phosphorylation compared to total GSK3-beta, indicating that 5-HT modulates beta-catenin protein levels by inhibiting GSK-3beta activation. |
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Formal Description Interaction-ID: 52744 |
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| Drugbank entries | Show/Hide entries for CTNNB1 |
| Comment | Since mechanical stimulation activates in osteoblasts the Wnt/beta-catenin pathway, the effects of serotonin (5-HT) on various elements of Wnt/beta-catenin pathway were examined. Beta-catenin protein was significantly increased 30 min after 5-HT exposure. 5-HT induced a significant increase in GSK-3beta phosphorylation compared to total GSK3-beta, indicating that 5-HT modulates beta-catenin protein levels by inhibiting GSK-3beta activation. |
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Formal Description Interaction-ID: 52745 |
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| Drugbank entries | Show/Hide entries for GSK3B |