CIDeRplusGeneral Information:
| Id: | 5,365 (click here to show other Interactions for entry) |
| Diseases: |
Coproporphyria, hereditary
- [OMIM]
Porphyria variegata - [OMIM] Porphyria, acute hepatic - [OMIM] Porphyria, acute intermittent - [OMIM] Porphyria, congenital erythropoietic - [OMIM] |
| Mammalia | |
| article/cited | |
| Reference: | Handschin C et al.(2005) Nutritional regulation of hepatic heme biosynthesis and porphyria through PGC-1alpha Cell 122: 505-515 [PMID: 16122419] |
Interaction Information:
| Comment | The heme biosynthetic pathway in eukaryotic cells is comprised of eight enzymatic steps; the first and the last three enzymes are located in the mitochondria, while the rest are in the cytoplasm: ALAS (mitochondrial), ALAD, PBGD (porphobilinogen deaminase), Uro-P (uroporphyrinogen) synthase, Uro-P decarboxylase, Cpo (mitochondrial), Proto-P oxidase (mitochondrial), ferrochelatase (mitochondrial). (cited information) |
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Formal Description Interaction-ID: 52401 |
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| Drugbank entries | Show/Hide entries for ALAS1 or Glycine |