CIDeRplusGeneral Information:
| Id: | 5,365 |
| Diseases: |
Coproporphyria, hereditary
- [OMIM]
Porphyria variegata - [OMIM] Porphyria, acute hepatic - [OMIM] Porphyria, acute intermittent - [OMIM] Porphyria, congenital erythropoietic - [OMIM] |
| Mammalia | |
| article/cited | |
| Reference: | Handschin C et al.(2005) Nutritional regulation of hepatic heme biosynthesis and porphyria through PGC-1alpha Cell 122: 505-515 [PMID: 16122419] |
Interaction Information:
| Comment | The heme biosynthetic pathway in eukaryotic cells is comprised of eight enzymatic steps; the first and the last three enzymes are located in the mitochondria, while the rest are in the cytoplasm: ALAS (mitochondrial), ALAD, PBGD, Uro-P synthase, Uro-P decarboxylase, Cpo (mitochondrial), Proto-P oxidase (mitochondrial), ferrochelatase (mitochondrial). (cited information) |
|
Formal Description Interaction-ID: 52364 |
|
| Drugbank entries | Show/Hide entries for ALAS1 |
| Comment | The heme biosynthetic pathway in eukaryotic cells is comprised of eight enzymatic steps; the first and the last three enzymes are located in the mitochondria, while the rest are in the cytoplasm: ALAS (mitochondrial), ALAD, PBGD, Uro-P synthase, Uro-P decarboxylase, Cpo (mitochondrial), Proto-P oxidase (mitochondrial), ferrochelatase (mitochondrial). (cited information) |
|
Formal Description Interaction-ID: 52365 |
|
| Drugbank entries | Show/Hide entries for ALAS2 |
| Comment | The heme biosynthetic pathway in eukaryotic cells is comprised of eight enzymatic steps; the first and the last three enzymes are located in the mitochondria, while the rest are in the cytoplasm: ALAS (mitochondrial), ALAD, PBGD, Uro-P synthase, Uro-P decarboxylase, Cpo (mitochondrial), Proto-P oxidase (mitochondrial), ferrochelatase (mitochondrial). (cited information) |
|
Formal Description Interaction-ID: 52366 |
|
| Drugbank entries | Show/Hide entries for ALAD |
| Comment | The heme biosynthetic pathway in eukaryotic cells is comprised of eight enzymatic steps; the first and the last three enzymes are located in the mitochondria, while the rest are in the cytoplasm: ALAS (mitochondrial), ALAD, PBGD (porphobilinogen deaminase), Uro-P synthase, Uro-P decarboxylase, Cpo (mitochondrial), Proto-P oxidase (mitochondrial), ferrochelatase (mitochondrial). (cited information) |
|
Formal Description Interaction-ID: 52367 |
|
| Comment | The heme biosynthetic pathway in eukaryotic cells is comprised of eight enzymatic steps; the first and the last three enzymes are located in the mitochondria, while the rest are in the cytoplasm: ALAS (mitochondrial), ALAD, PBGD (porphobilinogen deaminase), Uro-P (uroporphyrinogen) synthase, Uro-P decarboxylase, Cpo (mitochondrial), Proto-P oxidase (mitochondrial), ferrochelatase (mitochondrial). (cited information) |
|
Formal Description Interaction-ID: 52368 |
|
| Comment | The heme biosynthetic pathway in eukaryotic cells is comprised of eight enzymatic steps; the first and the last three enzymes are located in the mitochondria, while the rest are in the cytoplasm: ALAS (mitochondrial), ALAD, PBGD (porphobilinogen deaminase), Uro-P (uroporphyrinogen) synthase, Uro-P decarboxylase, Cpo (mitochondrial), Proto-P oxidase (mitochondrial), ferrochelatase (mitochondrial). (cited information) |
|
Formal Description Interaction-ID: 52378 |
|
| Drugbank entries | Show/Hide entries for UROD |
| Comment | The heme biosynthetic pathway in eukaryotic cells is comprised of eight enzymatic steps; the first and the last three enzymes are located in the mitochondria, while the rest are in the cytoplasm: ALAS (mitochondrial), ALAD, PBGD (porphobilinogen deaminase), Uro-P (uroporphyrinogen) synthase, Uro-P decarboxylase, Cpo (mitochondrial), Proto-P oxidase (mitochondrial), ferrochelatase (mitochondrial). (cited information) |
|
Formal Description Interaction-ID: 52379 |
|
| Comment | The heme biosynthetic pathway in eukaryotic cells is comprised of eight enzymatic steps; the first and the last three enzymes are located in the mitochondria, while the rest are in the cytoplasm: ALAS (mitochondrial), ALAD, PBGD (porphobilinogen deaminase), Uro-P (uroporphyrinogen) synthase, Uro-P decarboxylase, Cpo (mitochondrial), Proto-P oxidase (mitochondrial), ferrochelatase (mitochondrial). (cited information) |
|
Formal Description Interaction-ID: 52380 |
|
| Comment | The heme biosynthetic pathway in eukaryotic cells is comprised of eight enzymatic steps; the first and the last three enzymes are located in the mitochondria, while the rest are in the cytoplasm: ALAS (mitochondrial), ALAD, PBGD (porphobilinogen deaminase), Uro-P (uroporphyrinogen) synthase, Uro-P decarboxylase, Cpo (mitochondrial), Proto-P oxidase (mitochondrial), ferrochelatase (mitochondrial). (cited information) |
|
Formal Description Interaction-ID: 52381 |
|
| Drugbank entries | Show/Hide entries for FECH |
| Comment | The heme biosynthetic pathway in eukaryotic cells is comprised of eight enzymatic steps; the first and the last three enzymes are located in the mitochondria, while the rest are in the cytoplasm: ALAS (mitochondrial), ALAD, PBGD (porphobilinogen deaminase), Uro-P (uroporphyrinogen) synthase, Uro-P decarboxylase, Cpo (mitochondrial), Proto-P oxidase (mitochondrial), ferrochelatase (mitochondrial). (cited information) |
|
Formal Description Interaction-ID: 52382 |
|
| Drugbank entries | Show/Hide entries for FECH or Heme |
| Comment | The heme biosynthetic pathway in eukaryotic cells is comprised of eight enzymatic steps; the first and the last three enzymes are located in the mitochondria, while the rest are in the cytoplasm: ALAS (mitochondrial), ALAD, PBGD (porphobilinogen deaminase), Uro-P (uroporphyrinogen) synthase, Uro-P decarboxylase, Cpo (mitochondrial), Proto-P oxidase (mitochondrial), ferrochelatase (mitochondrial). (cited information) |
|
Formal Description Interaction-ID: 52383 |
|
| Drugbank entries | Show/Hide entries for FECH |
| Comment | The heme biosynthetic pathway in eukaryotic cells is comprised of eight enzymatic steps; the first and the last three enzymes are located in the mitochondria, while the rest are in the cytoplasm: ALAS (mitochondrial), ALAD, PBGD (porphobilinogen deaminase), Uro-P (uroporphyrinogen) synthase, Uro-P decarboxylase, Cpo (mitochondrial), Proto-P oxidase (mitochondrial), ferrochelatase (mitochondrial). (cited information) |
|
Formal Description Interaction-ID: 52384 |
|
| Comment | The heme biosynthetic pathway in eukaryotic cells is comprised of eight enzymatic steps; the first and the last three enzymes are located in the mitochondria, while the rest are in the cytoplasm: ALAS (mitochondrial), ALAD, PBGD (porphobilinogen deaminase), Uro-P (uroporphyrinogen) synthase, Uro-P decarboxylase, Cpo (mitochondrial), Proto-P oxidase (mitochondrial), ferrochelatase (mitochondrial). (cited information) |
|
Formal Description Interaction-ID: 52385 |
gene/protein decreases_quantity of drug/chemical compound |
| Comment | The heme biosynthetic pathway in eukaryotic cells is comprised of eight enzymatic steps; the first and the last three enzymes are located in the mitochondria, while the rest are in the cytoplasm: ALAS (mitochondrial), ALAD, PBGD (porphobilinogen deaminase), Uro-P (uroporphyrinogen) synthase, Uro-P decarboxylase, Cpo (mitochondrial), Proto-P oxidase (mitochondrial), ferrochelatase (mitochondrial). (cited information) |
|
Formal Description Interaction-ID: 52386 |
gene/protein increases_quantity of drug/chemical compound |
| Comment | The heme biosynthetic pathway in eukaryotic cells is comprised of eight enzymatic steps; the first and the last three enzymes are located in the mitochondria, while the rest are in the cytoplasm: ALAS (mitochondrial), ALAD, PBGD (porphobilinogen deaminase), Uro-P (uroporphyrinogen) synthase, Uro-P decarboxylase, Cpo (mitochondrial), Proto-P oxidase (mitochondrial), ferrochelatase (mitochondrial). (cited information) |
|
Formal Description Interaction-ID: 52387 |
gene/protein decreases_quantity of drug/chemical compound |
| Comment | The heme biosynthetic pathway in eukaryotic cells is comprised of eight enzymatic steps; the first and the last three enzymes are located in the mitochondria, while the rest are in the cytoplasm: ALAS (mitochondrial), ALAD, PBGD (porphobilinogen deaminase), Uro-P (uroporphyrinogen) synthase, Uro-P decarboxylase, Cpo (mitochondrial), Proto-P oxidase (mitochondrial), ferrochelatase (mitochondrial). (cited information) |
|
Formal Description Interaction-ID: 52388 |
|
| Drugbank entries | Show/Hide entries for UROD |
| Comment | The heme biosynthetic pathway in eukaryotic cells is comprised of eight enzymatic steps; the first and the last three enzymes are located in the mitochondria, while the rest are in the cytoplasm: ALAS (mitochondrial), ALAD, PBGD (porphobilinogen deaminase), Uro-P (uroporphyrinogen) synthase, Uro-P decarboxylase, Cpo (mitochondrial), Proto-P oxidase (mitochondrial), ferrochelatase (mitochondrial). (cited information) |
|
Formal Description Interaction-ID: 52389 |
|
| Drugbank entries | Show/Hide entries for UROD |
| Comment | The heme biosynthetic pathway in eukaryotic cells is comprised of eight enzymatic steps; the first and the last three enzymes are located in the mitochondria, while the rest are in the cytoplasm: ALAS (mitochondrial), ALAD, PBGD (porphobilinogen deaminase), Uro-P (uroporphyrinogen) synthase, Uro-P decarboxylase, Cpo (mitochondrial), Proto-P oxidase (mitochondrial), ferrochelatase (mitochondrial). (cited information) |
|
Formal Description Interaction-ID: 52391 |
|
| Comment | The heme biosynthetic pathway in eukaryotic cells is comprised of eight enzymatic steps; the first and the last three enzymes are located in the mitochondria, while the rest are in the cytoplasm: ALAS (mitochondrial), ALAD, PBGD (porphobilinogen deaminase), Uro-P (uroporphyrinogen) synthase, Uro-P decarboxylase, Cpo (mitochondrial), Proto-P oxidase (mitochondrial), ferrochelatase (mitochondrial). (cited information) |
|
Formal Description Interaction-ID: 52392 |
|
| Comment | The heme biosynthetic pathway in eukaryotic cells is comprised of eight enzymatic steps; the first and the last three enzymes are located in the mitochondria, while the rest are in the cytoplasm: ALAS (mitochondrial), ALAD, PBGD (porphobilinogen deaminase), Uro-P (uroporphyrinogen) synthase, Uro-P decarboxylase, Cpo (mitochondrial), Proto-P oxidase (mitochondrial), ferrochelatase (mitochondrial). (cited information) |
|
Formal Description Interaction-ID: 52394 |
|
| Comment | The heme biosynthetic pathway in eukaryotic cells is comprised of eight enzymatic steps; the first and the last three enzymes are located in the mitochondria, while the rest are in the cytoplasm: ALAS (mitochondrial), ALAD, PBGD (porphobilinogen deaminase), Uro-P (uroporphyrinogen) synthase, Uro-P decarboxylase, Cpo (mitochondrial), Proto-P oxidase (mitochondrial), ferrochelatase (mitochondrial). (cited information) |
|
Formal Description Interaction-ID: 52395 |
|
| Drugbank entries | Show/Hide entries for |
| Comment | The heme biosynthetic pathway in eukaryotic cells is comprised of eight enzymatic steps; the first and the last three enzymes are located in the mitochondria, while the rest are in the cytoplasm: ALAS (mitochondrial), ALAD, PBGD (porphobilinogen deaminase), Uro-P (uroporphyrinogen) synthase, Uro-P decarboxylase, Cpo (mitochondrial), Proto-P oxidase (mitochondrial), ferrochelatase (mitochondrial). (cited information) |
|
Formal Description Interaction-ID: 52397 |
|
| Drugbank entries | Show/Hide entries for ALAD or Porphobilinogen |
| Comment | The heme biosynthetic pathway in eukaryotic cells is comprised of eight enzymatic steps; the first and the last three enzymes are located in the mitochondria, while the rest are in the cytoplasm: ALAS (mitochondrial), ALAD, PBGD (porphobilinogen deaminase), Uro-P (uroporphyrinogen) synthase, Uro-P decarboxylase, Cpo (mitochondrial), Proto-P oxidase (mitochondrial), ferrochelatase (mitochondrial). (cited information) |
|
Formal Description Interaction-ID: 52398 |
|
| Drugbank entries | Show/Hide entries for ALAD |
| Comment | The heme biosynthetic pathway in eukaryotic cells is comprised of eight enzymatic steps; the first and the last three enzymes are located in the mitochondria, while the rest are in the cytoplasm: ALAS (mitochondrial), ALAD, PBGD (porphobilinogen deaminase), Uro-P (uroporphyrinogen) synthase, Uro-P decarboxylase, Cpo (mitochondrial), Proto-P oxidase (mitochondrial), ferrochelatase (mitochondrial). (cited information) |
|
Formal Description Interaction-ID: 52399 |
|
| Drugbank entries | Show/Hide entries for ALAS1 |
| Comment | The heme biosynthetic pathway in eukaryotic cells is comprised of eight enzymatic steps; the first and the last three enzymes are located in the mitochondria, while the rest are in the cytoplasm: ALAS (mitochondrial), ALAD, PBGD (porphobilinogen deaminase), Uro-P (uroporphyrinogen) synthase, Uro-P decarboxylase, Cpo (mitochondrial), Proto-P oxidase (mitochondrial), ferrochelatase (mitochondrial). (cited information) |
|
Formal Description Interaction-ID: 52400 |
|
| Drugbank entries | Show/Hide entries for ALAS2 |
| Comment | The heme biosynthetic pathway in eukaryotic cells is comprised of eight enzymatic steps; the first and the last three enzymes are located in the mitochondria, while the rest are in the cytoplasm: ALAS (mitochondrial), ALAD, PBGD (porphobilinogen deaminase), Uro-P (uroporphyrinogen) synthase, Uro-P decarboxylase, Cpo (mitochondrial), Proto-P oxidase (mitochondrial), ferrochelatase (mitochondrial). (cited information) |
|
Formal Description Interaction-ID: 52401 |
|
| Drugbank entries | Show/Hide entries for ALAS1 or Glycine |
| Comment | The heme biosynthetic pathway in eukaryotic cells is comprised of eight enzymatic steps; the first and the last three enzymes are located in the mitochondria, while the rest are in the cytoplasm: ALAS (mitochondrial), ALAD, PBGD (porphobilinogen deaminase), Uro-P (uroporphyrinogen) synthase, Uro-P decarboxylase, Cpo (mitochondrial), Proto-P oxidase (mitochondrial), ferrochelatase (mitochondrial). (cited information) |
|
Formal Description Interaction-ID: 52402 |
|
| Drugbank entries | Show/Hide entries for ALAS1 |
| Comment | The heme biosynthetic pathway in eukaryotic cells is comprised of eight enzymatic steps; the first and the last three enzymes are located in the mitochondria, while the rest are in the cytoplasm: ALAS (mitochondrial), ALAD, PBGD (porphobilinogen deaminase), Uro-P (uroporphyrinogen) synthase, Uro-P decarboxylase, Cpo (mitochondrial), Proto-P oxidase (mitochondrial), ferrochelatase (mitochondrial). (cited information) |
|
Formal Description Interaction-ID: 52403 |
|
| Drugbank entries | Show/Hide entries for ALAS2 or Glycine |
| Comment | The heme biosynthetic pathway in eukaryotic cells is comprised of eight enzymatic steps; the first and the last three enzymes are located in the mitochondria, while the rest are in the cytoplasm: ALAS (mitochondrial), ALAD, PBGD (porphobilinogen deaminase), Uro-P (uroporphyrinogen) synthase, Uro-P decarboxylase, Cpo (mitochondrial), Proto-P oxidase (mitochondrial), ferrochelatase (mitochondrial). (cited information) |
|
Formal Description Interaction-ID: 52404 |
|
| Drugbank entries | Show/Hide entries for ALAS2 |
| Comment | The main clinical manifestations of porphyrias are intermittent attacks of neuropsychiatric dysfunction and/or sensitivity of the skin to sunlight. The neuropsychiatric syndrome occurs only in those porphyrias in which there is intermittent induction of hepatic ALAS-1 and consequent increased urinary excretion of delta-aminolevulinic acid (ALA). Attacks are characteristically precipitated by drugs such as barbiturates, fasting, and hormones and result in abdominal pain, tachycardia, peripheral motor neuropathies, psychosis, and other mental disturbances. (cited information) |
|
Formal Description Interaction-ID: 52405 |
disease Porphyria affects_activity of phenotype neuropsychiatric dysfunction |
| Comment | The main clinical manifestations of porphyrias are intermittent attacks of neuropsychiatric dysfunction and/or sensitivity of the skin to sunlight. The neuropsychiatric syndrome occurs only in those porphyrias in which there is intermittent induction of hepatic ALAS-1 and consequent increased urinary excretion of delta-aminolevulinic acid (ALA). Attacks are characteristically precipitated by drugs such as barbiturates, fasting, and hormones and result in abdominal pain, tachycardia, peripheral motor neuropathies, psychosis, and other mental disturbances. (cited information) |
|
Formal Description Interaction-ID: 52409 |
disease Porphyria affects_activity of phenotype increased skin sensitivity to sunlight |
| Comment | The main clinical manifestations of porphyrias are intermittent attacks of neuropsychiatric dysfunction and/or sensitivity of the skin to sunlight. The neuropsychiatric syndrome occurs only in those porphyrias in which there is intermittent induction of hepatic ALAS-1 and consequent increased urinary excretion of delta-aminolevulinic acid (ALA). Attacks are characteristically precipitated by drugs such as barbiturates, fasting, and hormones and result in abdominal pain, tachycardia, peripheral motor neuropathies, psychosis, and other mental disturbances. (cited information) |
|
Formal Description Interaction-ID: 52412 |
|
| Drugbank entries | Show/Hide entries for ALAS1 |
| Comment | Porphyria attacks are characteristically precipitated by drugs such as barbiturates, fasting, and hormones and result in abdominal pain, tachycardia, peripheral motor neuropathies, psychosis, and other mental disturbances. (cited information) |
|
Formal Description Interaction-ID: 52414 |
|
| Comment | Porphyria attacks are characteristically precipitated by drugs such as barbiturates, fasting, and hormones and result in abdominal pain, tachycardia, peripheral motor neuropathies, psychosis, and other mental disturbances. (cited information) |
|
Formal Description Interaction-ID: 52415 |
environment fasting increases_activity of disease Porphyria |
| Comment | Porphyria attacks are characteristically precipitated by drugs such as barbiturates, fasting, and hormones and result in abdominal pain, tachycardia, peripheral motor neuropathies, psychosis, and other mental disturbances. (cited information) |
|
Formal Description Interaction-ID: 52416 |
drug/chemical compound Hormone increases_activity of disease Porphyria |
| Comment | Inducible hepatic porphyrias are caused by rare defects in delta-aminolevulinic acid dehydratase (ALAD), porphobilinogen deaminase (PBGD, also known as hydroxymethylbilane synthase), coproporphyrinogen oxidase, and protoporphyrinogen oxidase. The classical names for the corresponding diseases are ALAD deficiency, acute intermittent porphyria, hereditary coproporphyria, and variegate porphyria. (cited information) |
|
Formal Description Interaction-ID: 52417 |
|
| Drugbank entries | Show/Hide entries for ALAD |
| Comment | Inducible hepatic porphyrias are caused by rare defects in delta-aminolevulinic acid dehydratase (ALAD), porphobilinogen deaminase (PBGD, also known as hydroxymethylbilane synthase), coproporphyrinogen oxidase, and protoporphyrinogen oxidase. The classical names for the corresponding diseases are ALAD deficiency, acute intermittent porphyria, hereditary coproporphyria, and variegate porphyria. (cited information) |
|
Formal Description Interaction-ID: 52460 |
|
| Comment | Inducible hepatic porphyrias are caused by rare defects in delta-aminolevulinic acid dehydratase (ALAD), porphobilinogen deaminase (PBGD, also known as hydroxymethylbilane synthase), coproporphyrinogen oxidase, and protoporphyrinogen oxidase. The classical names for the corresponding diseases are ALAD deficiency, acute intermittent porphyria, hereditary coproporphyria, and variegate porphyria. (cited information) |
|
Formal Description Interaction-ID: 52461 |
|
| Comment | Inducible hepatic porphyrias are caused by rare defects in delta-aminolevulinic acid dehydratase (ALAD), porphobilinogen deaminase (PBGD, also known as hydroxymethylbilane synthase), coproporphyrinogen oxidase, and protoporphyrinogen oxidase. The classical names for the corresponding diseases are ALAD deficiency, acute intermittent porphyria, hereditary coproporphyria, and variegate porphyria. (cited information) |
|
Formal Description Interaction-ID: 52462 |
|
| Comment | Heme directly represses its own biosynthesis in a negative feedback loop. (cited information) |
|
Formal Description Interaction-ID: 52463 |
|
| Drugbank entries | Show/Hide entries for Heme |
| Comment | In the liver, PGC-1alpha is induced during fasting, when the liver ceases using glucose as an energy supply and changes to the beta-oxidation of fatty acids. This increase in fatty-acid beta-oxidation and elevation of hepatic gluconeogenesis are both under control of PGC-1alpha. (cited information) |
|
Formal Description Interaction-ID: 52464 |
|
| Comment | In the liver, PGC-1alpha is induced during fasting, when the liver ceases using glucose as an energy supply and changes to the beta-oxidation of fatty acids. This increase in fatty-acid beta-oxidation and elevation of hepatic gluconeogenesis are both under control of PGC-1alpha. (cited information) |
|
Formal Description Interaction-ID: 52465 |
|
| Comment | In the liver, PGC-1alpha is induced during fasting, when the liver ceases using glucose as an energy supply and changes to the beta-oxidation of fatty acids. This increase in fatty-acid beta-oxidation and elevation of hepatic gluconeogenesis are both under control of PGC-1alpha. (cited information) |
|
Formal Description Interaction-ID: 52466 |
|
| Comment | The induction of PGC-1alpha in fasting has previously been shown to be a consequence of glucagon action and the transcription factor cAMP element binding protein (CREB), which binds directly to the PGC-1alpha promoter. In addition, CREB can also directly activate the ALAS-1 promoter. (cited information) |
|
Formal Description Interaction-ID: 52470 |
|
| Comment | The induction of PGC-1alpha in fasting has previously been shown to be a consequence of glucagon action and the transcription factor cAMP element binding protein (CREB), which binds directly to the PGC-1alpha promoter. In addition, CREB can also directly activate the ALAS-1 promoter. (cited information) |
|
Formal Description Interaction-ID: 52472 |
|
| Comment | The induction of PGC-1alpha in fasting has previously been shown to be a consequence of glucagon action and the transcription factor cAMP element binding protein (CREB), which binds directly to the PGC-1alpha promoter. In addition, CREB can also directly activate the ALAS-1 promoter. (cited information) |
|
Formal Description Interaction-ID: 52473 |
|
| Drugbank entries | Show/Hide entries for CREB1 |
| Comment | The induction of PGC-1alpha in fasting has previously been shown to be a consequence of glucagon action and the transcription factor cAMP element binding protein (CREB), which binds directly to the PGC-1alpha promoter. In addition, CREB can also directly activate the ALAS-1 promoter. (cited information) |
|
Formal Description Interaction-ID: 52474 |
|
| Drugbank entries | Show/Hide entries for CREB1 or ALAS1 |
| Comment | The therapeutic effect of glucose on acute hepatic porphyria is well documented. (cited information) |
|
Formal Description Interaction-ID: 52475 |
|
| Comment | ALAS-1 transcription is inhibited by the insulin pathway involving Akt. (cited information) |
|
Formal Description Interaction-ID: 52477 |
|
| Drugbank entries | Show/Hide entries for ALAS1 |
| Comment | Insulin has been shown to activate the protein kinase Akt in the liver, and Akt in turn phosphorylates FOXO1. Phosphorylation of FOXO1 results in disruption of its binding to PGC-1alpha and its export from the nucleus, thus inhibiting PGC-1alpha action. (cited information) |
|
Formal Description Interaction-ID: 52478 |
gene/protein decreases_quantity of complex/PPI FOXO1-PPARGC1A complex |
| Drugbank entries | Show/Hide entries for AKT1 |
| Comment | Insulin has been shown to activate the protein kinase Akt in the liver, and Akt in turn phosphorylates FOXO1. Phosphorylation of FOXO1 results in disruption of its binding to PGC-1alpha and its export from the nucleus, thus inhibiting PGC-1alpha action. (cited information) |
|
Formal Description Interaction-ID: 52479 |
|
| Drugbank entries | Show/Hide entries for AKT1 |
| Comment | Like insulin, glucose has been shown to have an inhibitory effect on ALAS-1 transcription in cell culture. (cited information) |
|
Formal Description Interaction-ID: 52480 |
|
| Drugbank entries | Show/Hide entries for ALAS1 |