CIDeRplusGeneral Information:
| Id: | 4,928 (click here to show other Interactions for entry) |
| Diseases: |
Diabetes mellitus, type II
- [OMIM]
Insulin resistance |
| Homo sapiens | |
| Europeans | |
| article | |
| Reference: | Floegel A et al.(2013) Identification of serum metabolites associated with risk of type 2 diabetes using a targeted metabolomic approach Diabetes 62: 639-648 [PMID: 23043162] |
Interaction Information:
| Comment | The association between serum metabolites measured by targeted metabolomics and risk of T2D was investigated in the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam (27,548 adults) among all incident cases of T2D (n = 800, mean follow-up 7 years) and a randomly drawn subcohort (n = 2,282). Flow injection analysis tandem mass spectrometry was used to quantify 163 metabolites, including acylcarnitines, amino acids, hexose, and phospholipids, in baseline serum samples. Serum hexose; phenylalanine; and diacyl-phosphatidylcholines C32:1, C36:1, C38:3, and C40:5 were independently associated with increased risk of T2D and serum glycine; sphingomyelin C16:1; acyl-alkyl-phosphatidylcholines C34:3, C40:6, C42:5, C44:4, and C44:5; and lysophosphatidylcholine C18:2 with decreased risk. |
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Formal Description Interaction-ID: 48751 |
disease decreases_quantity of drug/chemical compound |
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