General Information:

Id: 4,765 (click here to show other Interactions for entry)
Diseases: Cardiovascular disease
Metabolic
Mammalia
article
Reference: Breard M and Grillon C(2009) Serotonin binds to purified neuronal nitric oxide synthase: a possible explanation for ROS production induced by 5HT in the presence of nNOS Free Radic. Res. 43: 206-213 [PMID: 19191108]

Interaction Information:

Comment Serotonin (5HT) binds to nNOS in the presence of superoxide anions. Addition of catalase or superoxide scavengers (SOD, ascorbic acid or cysteine) to the reaction mixture totally prevented 5HT binding.
Formal Description
Interaction-ID: 47184

drug/chemical compound

Serotonin

interacts (colocalizes) with

gene/protein

NOS1

but only when the enzyme is active and in a superoxide-dependent manner, resulting in increased levels of ROS
Drugbank entries Show/Hide entries for NOS1