General Information:

Id: 4,765
Diseases: Cardiovascular disease
Metabolic
Mammalia
article
Reference: Breard M and Grillon C(2009) Serotonin binds to purified neuronal nitric oxide synthase: a possible explanation for ROS production induced by 5HT in the presence of nNOS Free Radic. Res. 43: 206-213 [PMID: 19191108]

Interaction Information:

Comment Serotonin (5HT) binds to nNOS in the presence of superoxide anions. Addition of catalase or superoxide scavengers (SOD, ascorbic acid or cysteine) to the reaction mixture totally prevented 5HT binding.
Formal Description
Interaction-ID: 47184

drug/chemical compound

Serotonin

interacts (colocalizes) with

gene/protein

NOS1

but only when the enzyme is active and in a superoxide-dependent manner, resulting in increased levels of ROS
Drugbank entries Show/Hide entries for NOS1
Comment Serotonin (5HT) induced the production of ROS (H2O2 and O2-) in the presence of nNOS.
Formal Description
Interaction-ID: 47186

drug/chemical compound

Serotonin

increases_quantity of

drug/chemical compound

Reactive oxygen species

in the presence of nNOS