General Information:

Id: 4,523 (click here to show other Interactions for entry)
Diseases: Cardiovascular disease
Metabolic
Rattus norvegicus
male
Sprague-Dawley rat
aorta, heart tissue, smooth muscle cell (SMC)
article
Reference: El Midaoui A et al.(2006) Modulation of cardiac and aortic peroxisome proliferator-activated receptor-gamma expression by oxidative stress in chronically glucose-fed rats Am. J. Hypertens. 19: 407-412 [PMID: 16580578]

Interaction Information:

Comment Chronic glucose feeding (10% glucose in addition to normal chow diet for 4 weeks) resulted in significant decrease of PPARgamma level in aorta and heart tissues. Supplementation of alpha-lipoic acid not only prevented the decrease of PPARgamma, but also increased PPARgamma levels in aorta and heart tissues.
Formal Description
Interaction-ID: 45277

drug/chemical compound

Lipoate

increases_quantity of

gene/protein

PPARG

in aorta and heart tissue
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