CIDeRplusGeneral Information:
| Id: | 4,523 |
| Diseases: |
Cardiovascular disease
Metabolic |
| Rattus norvegicus | |
| male | |
| Sprague-Dawley rat | |
| aorta, heart tissue, smooth muscle cell (SMC) | |
| article | |
| Reference: | El Midaoui A et al.(2006) Modulation of cardiac and aortic peroxisome proliferator-activated receptor-gamma expression by oxidative stress in chronically glucose-fed rats Am. J. Hypertens. 19: 407-412 [PMID: 16580578] |
Interaction Information:
| Comment | After chronic glucose feeding (10% glucose in addition to normal chow diet for 4 weeks), the systolic blood pressure increases significantly. |
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Formal Description Interaction-ID: 45139 |
phenotype increases_activity of |
| Comment | Chronic glucose feeding (10% glucose in addition to normal chow diet for 4 weeks) resulted in a significant increase in plasma levels of glucose. |
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Formal Description Interaction-ID: 45140 |
|
| Comment | Chronic glucose feeding and subsequent supplementation with alpha-lipoic acid resulted in a significant increase in plasma levels of glucose. |
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Formal Description Interaction-ID: 45161 |
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| Comment | Chronic glucose feeding (10% glucose in addition to normal chow diet for 4 weeks) resulted in a significant increase in plasma insulin level. |
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Formal Description Interaction-ID: 45171 |
phenotype increases_activity of phenotype |
| Comment | Chronic glucose feeding (10% glucose in addition to normal chow diet for 4 weeks) resulted in a significant elevation of insulin resistance index, as expressed by HOMA. |
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Formal Description Interaction-ID: 45175 |
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| Comment | Chronic glucose feeding and subsequent supplementation with alpha-lipoic acid reduces the elevated insulin level. |
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Formal Description Interaction-ID: 45176 |
drug/chemical compound decreases_activity of phenotype |
| Comment | Chronic glucose feeding (10% glucose in addition to normal chow diet for 4 weeks) resulted in a significant elevation of insulin resistance index, as expressed by HOMA. Subsequent treatment with alpha-lipoic acid attenuated this increase. |
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Formal Description Interaction-ID: 45273 |
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| Comment | The basal aortic O2- level significantly increased in glucose-fed mice (10% glucose in addition to normal chow diet for 4 weeks). Subsequent treatment with alpha-lipoic acid decreases the O2- production. |
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Formal Description Interaction-ID: 45274 |
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| Comment | The basal aortic O2- level significantly increased in glucose-fed mice (10% glucose in addition to normal chow diet for 4 weeks). Subsequent treatment with alpha-lipoic acid decreases the O2- production. |
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Formal Description Interaction-ID: 45275 |
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| Comment | Chronic glucose feeding (10% glucose in addition to normal chow diet for 4 weeks) resulted in significant decrease of PPARgamma level in aorta and heart tissues. Supplementation of alpha-lipoic acid not only prevented the decrease of PPARgamma, but also increased PPARgamma levels in aorta and heart tissues. |
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Formal Description Interaction-ID: 45276 |
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| Drugbank entries | Show/Hide entries for PPARG |
| Comment | Chronic glucose feeding (10% glucose in addition to normal chow diet for 4 weeks) resulted in significant decrease of PPARgamma level in aorta and heart tissues. Supplementation of alpha-lipoic acid not only prevented the decrease of PPARgamma, but also increased PPARgamma levels in aorta and heart tissues. |
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Formal Description Interaction-ID: 45277 |
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| Drugbank entries | Show/Hide entries for PPARG |
| Comment | PPARalpha levels were unchanged in aorta and heart tissues after 4 weeks of either glucose or lipoic acid supplementation. |
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Formal Description Interaction-ID: 45278 |
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| Drugbank entries | Show/Hide entries for PPARA |
| Comment | PPARalpha levels were unchanged in aorta and heart tissues after 4 weeks of either glucose or lipoic acid supplementation. |
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Formal Description Interaction-ID: 45279 |
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| Drugbank entries | Show/Hide entries for PPARA |
| Comment | Chronic treatment of SMCs (smooth muscle cells) with high insulin levels increased the O2- production. |
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Formal Description Interaction-ID: 45280 |
phenotype increases_quantity of drug/chemical compound |
| Comment | After chronic glucose feeding (10% glucose in addition to normal chow diet for 4 weeks), the systolic blood pressure increases significantly. Supplementation with alpha-lipoic acid prevented this increase. |
|
Formal Description Interaction-ID: 45281 |
drug/chemical compound decreases_activity of |
| Comment | Addition of Pioglitazone, an agonist for PPARgamma, attenuated the increase in O2- production in high insulin-treated SMCs (smooth muscle cells). |
|
Formal Description Interaction-ID: 45374 |
drug/chemical compound decreases_quantity of drug/chemical compound |
| Drugbank entries | Show/Hide entries for Pioglitazone |
| Comment | Addition of Pioglitazone, an agonist for PPARgamma, attenuated the increase in O2- production in high insulin-treated SMCs (smooth muscle cells). |
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Formal Description Interaction-ID: 45592 |
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| Drugbank entries | Show/Hide entries for PPARG |