General Information:

Id: 38 (click here to show other Interactions for entry)
Diseases: Amyotrophic lateral sclerosis
Rattus norvegicus
BTO:0000938 neuron
article
Reference: Semenova MM et al.(2007) Rho mediates calcium-dependent activation of p38alpha and subsequent excitotoxic cell death Nat. Neurosci. 10: 436-443 [PMID: 17369826]

Interaction Information:

Comment The treatment of cerebellar granule neurons with glutamate induces apoptosis, with many of the morphological and biochemical features of excitotoxic neuronal death in the brain, through a pathway that requires Mapk14 (p38alpha). Glutamate activates Mapk14 (p38alpha) with a characteristic rapid timecourse.
Formal Description
Interaction-ID: 89

drug/chemical compound

Glutamate

increases_activity of

gene/protein

MAPK14

in cultured cerebellar granule (CBG) neurons and brain tissue
Drugbank entries Show/Hide entries for MAPK14