General Information:

Id: 38
Diseases: Amyotrophic lateral sclerosis
Rattus norvegicus
BTO:0000938 neuron
article
Reference: Semenova MM et al.(2007) Rho mediates calcium-dependent activation of p38alpha and subsequent excitotoxic cell death Nat. Neurosci. 10: 436-443 [PMID: 17369826]

Interaction Information:

Comment The treatment of cerebellar granule neurons with glutamate induces apoptosis, with many of the morphological and biochemical features of excitotoxic neuronal death in the brain, through a pathway that requires Mapk14 (p38alpha). Glutamate activates Mapk14 (p38alpha) with a characteristic rapid timecourse.
Formal Description
Interaction-ID: 89

drug/chemical compound

Glutamate

increases_activity of

gene/protein

MAPK14

in cultured cerebellar granule (CBG) neurons and brain tissue
Drugbank entries Show/Hide entries for MAPK14
Comment Glutamate activates Mapk14 (p38alpha) as a result of RhoA activation.
Formal Description
Interaction-ID: 605

drug/chemical compound

Glutamate

increases_activity of

gene/protein

RHOA

in cultured cerebellar granule (CBG) neurons and brain tissue
Drugbank entries Show/Hide entries for RHOA
Comment Glutamate activates Mapk14 (p38alpha) as a result of Rho activation. Results indicate that active Rho is sufficient to activate p38alpha, but only in primary cultured neurons.
Formal Description
Interaction-ID: 609

gene/protein

RHOA

increases_activity of

gene/protein

MAPK14

in cultured cerebellar granule (CBG) neurons and brain tissue
Drugbank entries Show/Hide entries for RHOA or MAPK14
Comment Active Rho induces pyknosis only in primary cultured neurons, and co-expression of Bcl-2 prevented this response, as it does for glutamate-induced death in this system. Pyknosis is an early indicator of glutamate-induced death in cerebellar granule neurons.
Formal Description
Interaction-ID: 616

gene/protein

RHOA

increases_activity of

process

neuron apoptotic process

in cultured cerebellar granule (CBG) neurons and brain tissue
Drugbank entries Show/Hide entries for RHOA