General Information:

Id: 3,285 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Mus musculus
APP/PS1 mouse
article
Reference: Jardanhazi-Kurutz D et al.(2011) Distinct adrenergic system changes and neuroinflammation in response to induced locus ceruleus degeneration in APP/PS1 transgenic mice Neuroscience 176: 396-407 [PMID: 21129451]

Interaction Information:

Comment Degeneration of locus ceruleus (LC) neurons and subsequent reduction of norepinephrine (NE) in LC projection areas represent an early pathological indicator of Alzheimer's disease (AD).
Formal Description
Interaction-ID: 30222

disease

Alzheimer disease

decreases_quantity of

drug/chemical compound

Noradrenaline