CIDeRplusGeneral Information:
| Id: | 3,285 |
| Diseases: |
Alzheimer disease
- [OMIM]
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| Mus musculus | |
| APP/PS1 mouse | |
| article | |
| Reference: | Jardanhazi-Kurutz D et al.(2011) Distinct adrenergic system changes and neuroinflammation in response to induced locus ceruleus degeneration in APP/PS1 transgenic mice Neuroscience 176: 396-407 [PMID: 21129451] |
Interaction Information:
| Comment | Degeneration of locus ceruleus (LC) neurons and subsequent reduction of norepinephrine (NE) in LC projection areas represent an early pathological indicator of Alzheimer's disease (AD). |
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Formal Description Interaction-ID: 30216 |
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| Comment | Degeneration of locus ceruleus (LC) neurons and subsequent reduction of norepinephrine (NE) in LC projection areas represent an early pathological indicator of Alzheimer's disease (AD). |
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Formal Description Interaction-ID: 30222 |
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| Comment | LC (locus ceruleus) degeneration can be induced in 3-month-old APP/PS1 mice by the neurotoxin N-(2-chloroethyl)-N-ethyl-bromo-benzylamine (dsp4). |
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Formal Description Interaction-ID: 30224 |
drug/chemical compound DSP4 affects_quantity of tissue/cell line |
| Comment | Expression of beta-1-adrenoceptor was influenced by norepinephrine (NE) depletion and aging. |
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Formal Description Interaction-ID: 30244 |
drug/chemical compound affects_expression of gene/protein |
| Drugbank entries | Show/Hide entries for ADRB1 |
| Comment | Expression of beta-1-adrenoceptor was influenced by norepinephrine (NE) depletion and aging. Alpha-2 adrenergic receptors show minor alterations, no differences were found in alpha-2A- and alpha-2C-AR mRNA levels. |
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Formal Description Interaction-ID: 30245 |
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| Drugbank entries | Show/Hide entries for ADRB1 |
| Comment | Expression of alpha-1-adrenoceptors was influenced by aging, APP and PS1 overexpression, and norepinephrine (NE) depletion. |
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Formal Description Interaction-ID: 30246 |
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| Drugbank entries | Show/Hide entries for ADRA1D |
| Comment | Expression of alpha-1-adrenoceptors was influenced by aging, APP and PS1 overexpression, and norepinephrine (NE) depletion. |
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Formal Description Interaction-ID: 30247 |
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| Drugbank entries | Show/Hide entries for APP or ADRA1D |
| Comment | The expression of the pro-inflammatory cytokines CCL2 and IL-1beta were induced in both, dsp4-treated and APP/PS1-transgenic mice, whereas IL-1alpha was only up-regulated in dsp4-treated APP/PS1 mice. |
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Formal Description Interaction-ID: 30249 |
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| Drugbank entries | Show/Hide entries for CCL2 |
| Comment | The expression of the pro-inflammatory cytokines CCL2 and IL-1beta were induced in both, dsp4-treated and APP/PS1-transgenic mice, whereas IL-1alpha was only up-regulated in dsp4-treated APP/PS1 mice. |
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Formal Description Interaction-ID: 30250 |
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| Drugbank entries | Show/Hide entries for CCL2 |
| Comment | The expression of the pro-inflammatory cytokines CCL2 and IL-1beta were induced in both, dsp4-treated and APP/PS1-transgenic mice, whereas IL-1alpha was only up-regulated in dsp4-treated APP/PS1 mice. |
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Formal Description Interaction-ID: 30251 |
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| Drugbank entries | Show/Hide entries for IL1B |
| Comment | The expression of the pro-inflammatory cytokines CCL2 and IL-1beta were induced in both, dsp4-treated and APP/PS1-transgenic mice, whereas IL-1alpha was only up-regulated in dsp4-treated APP/PS1 mice. |
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Formal Description Interaction-ID: 30252 |
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| Drugbank entries | Show/Hide entries for IL1B |
| Comment | The expression of the pro-inflammatory cytokines CCL2 and IL-1beta were induced in both, dsp4-treated and APP/PS1-transgenic mice, whereas IL-1alpha was only up-regulated in dsp4-treated APP/PS1 mice. |
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Formal Description Interaction-ID: 30253 |
organism model APP/PS1 mouse increases_expression of gene/protein |
| Comment | Concerning amyloid beta (Abeta) deposition, we observed an elevation of Abeta 1-42 levels in aged dsp4-treated APP/PS1 mice. |
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Formal Description Interaction-ID: 30257 |
organism model APP/PS1 mouse increases_quantity of gene/protein |