General Information:

Id: 3,120 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Rattus norvegicus
male
article
Reference: Shin AC et al.(2010) Chronic exposure to a high-fat diet affects stress axis function differentially in diet-induced obese and diet-resistant rats. Int J Obes (Lond) 34: 1218-1226 [PMID: 20212497]

Interaction Information:

Comment High-fat diet increased paraventricular nucleus (PVN) norepinephrine (NE) in both diet-induced obese (DIO) and diet-resistant (DR) rats. This was accompanied by increases in corticotrophin-releasing hormone (CRH) and corticosterone (CORT) secretion only in DR animals, but not in DIO rats.
Formal Description
Interaction-ID: 28651

environment

high-fat diet

increases_quantity of

drug/chemical compound

Noradrenaline

in the paraventricular nucleus