CIDeRplusGeneral Information:
| Id: | 3,120 |
| Diseases: |
Diabetes mellitus, type II
- [OMIM]
Insulin resistance |
| Rattus norvegicus | |
| male | |
| article | |
| Reference: | Shin AC et al.(2010) Chronic exposure to a high-fat diet affects stress axis function differentially in diet-induced obese and diet-resistant rats. Int J Obes (Lond) 34: 1218-1226 [PMID: 20212497] |
Interaction Information:
| Comment | High-fat diet increased paraventricular nucleus (PVN) norepinephrine (NE) in both diet-induced obese (DIO) and diet-resistant (DR) rats. This was accompanied by increases in corticotrophin-releasing hormone (CRH) and corticosterone (CORT) secretion only in DR animals, but not in DIO rats. |
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Formal Description Interaction-ID: 28651 |
environment high-fat diet increases_quantity of drug/chemical compound |
| Comment | High-fat diet increased paraventricular nucleus (PVN) norepinephrine (NE) in both diet-induced obese (DIO) and diet-resistant (DR) rats. This was accompanied by increases in corticotrophin-releasing hormone (CRH) and corticosterone (CORT) secretion only in DR animals, but not in DIO rats. |
|
Formal Description Interaction-ID: 28652 |
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| Drugbank entries | Show/Hide entries for CRH |
| Comment | High-fat diet increased paraventricular nucleus (PVN) norepinephrine (NE) in both diet-induced obese (DIO) and diet-resistant (DR) rats. This was accompanied by increases in corticotrophin-releasing hormone (CRH) and corticosterone (CORT) secretion only in DR animals, but not in DIO rats. |
|
Formal Description Interaction-ID: 28653 |
environment high-fat diet increases_quantity of drug/chemical compound |
| Comment | High-fat diet increased paraventricular nucleus (PVN) norepinephrine (NE) in both diet-induced obese (DIO) and diet-resistant (DR) rats. This was accompanied by increases in corticotrophin-releasing hormone (CRH) and corticosterone (CORT) secretion only in DR animals, but not in DIO rats. |
|
Formal Description Interaction-ID: 28654 |
|
| Drugbank entries | Show/Hide entries for CRH |
| Comment | High-fat diet increased paraventricular nucleus (PVN) norepinephrine (NE) in both diet-induced obese (DIO) and diet-resistant (DR) rats. This was accompanied by increases in corticotrophin-releasing hormone (CRH) and corticosterone (CORT) secretion only in DR animals, but not in DIO rats. |
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Formal Description Interaction-ID: 28655 |
environment high-fat diet NOT increases_quantity of drug/chemical compound |
| Comment | Long-form functional leptin receptor (ObRb) mRNA levels in the brainstem noradrenergic areas were not affected by high-fat diet in both DIO and DR rats. |
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Formal Description Interaction-ID: 28656 |
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| Comment | HF diet increased tyrosine hydroxylase (TH) mRNA levels only in DIO rats, not in DR rats. |
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Formal Description Interaction-ID: 28661 |
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| Drugbank entries | Show/Hide entries for TH |
| Comment | HF diet increased tyrosine hydroxylase (TH) mRNA levels only in DIO rats, not in DR rats. |
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Formal Description Interaction-ID: 28678 |
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| Drugbank entries | Show/Hide entries for TH |
| Comment | HF diet per se acts as a stressor, stimulating hypothalamo-pituitary-adrenal (HPA) axis activity resulting in elevated glucocorticoid levels. |
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Formal Description Interaction-ID: 28679 |
environment high-fat diet increases_activity of process HPA axis |