CIDeRplusGeneral Information:
| Id: | 2,286 (click here to show other Interactions for entry) |
| Diseases: |
Diabetes mellitus, type II
- [OMIM]
Insulin resistance |
| Homo sapiens | |
| article | |
| Reference: | Illig T et al.(2010) A genome-wide perspective of genetic variation in human metabolism. Nat. Genet. 42: 137-141 [PMID: 20037589] |
Interaction Information:
| Comment | Eight of nine replicated genetic polymorphisms and also four of five suggestive loci are located in or near genes encoding enzymes that are central to the different processes in human lipid metabolism, including beta-oxidation (ACADS, ACADM and ACADL), polyunsaturated fatty acid biosynthesis (FADS1 and ELOVL2), fatty acid synthesis (SCD), breakdown of fats and proteins to energy (ETFDH) and biosynthesis of phospholipids (SPTLC3). Two SNPs are located in or near genes encoding carrier proteins (SLC22A4 and SLC16A9), and two SNPs involve enzymes that are related to amino acid metabolism (PHGDH and CPS1). Only for two genetic variants does the attribution of a metabolic function remain elusive (PLEKHH1 and SYNE2). |
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Formal Description Interaction-ID: 19497 |
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