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General Information:

Id:	2,286
Diseases:	Diabetes mellitus, type II - [OMIM] Insulin resistance
Organism:	Homo sapiens
Publication type:	article
Reference:	Illig T et al.(2010) A genome-wide perspective of genetic variation in human metabolism. Nat. Genet. 42: 137-141 [PMID: 20037589]

Interaction Information:

Comment	Eight of nine replicated genetic polymorphisms and also four of five suggestive loci are located in or near genes encoding enzymes that are central to the different processes in human lipid metabolism, including beta-oxidation (ACADS, ACADM and ACADL), polyunsaturated fatty acid biosynthesis (FADS1 and ELOVL2), fatty acid synthesis (SCD), breakdown of fats and proteins to energy (ETFDH) and biosynthesis of phospholipids (SPTLC3). Two SNPs are located in or near genes encoding carrier proteins (SLC22A4 and SLC16A9), and two SNPs involve enzymes that are related to amino acid metabolism (PHGDH and CPS1). Only for two genetic variants does the attribution of a metabolic function remain elusive (PLEKHH1 and SYNE2).
Formal Description Interaction-ID: 19471	SNP FADS1 rs174547 affects_quantity of drug/chemical compound PC aa C36:3

Comment	Eight of nine replicated genetic polymorphisms and also four of five suggestive loci are located in or near genes encoding enzymes that are central to the different processes in human lipid metabolism, including beta-oxidation (ACADS, ACADM and ACADL), polyunsaturated fatty acid biosynthesis (FADS1 and ELOVL2), fatty acid synthesis (SCD), breakdown of fats and proteins to energy (ETFDH) and biosynthesis of phospholipids (SPTLC3). Two SNPs are located in or near genes encoding carrier proteins (SLC22A4 and SLC16A9), and two SNPs involve enzymes that are related to amino acid metabolism (PHGDH and CPS1). Only for two genetic variants does the attribution of a metabolic function remain elusive (PLEKHH1 and SYNE2).
Formal Description Interaction-ID: 19488	SNP FADS1 rs174547 affects_quantity of drug/chemical compound PC aa C36:4

Comment	Eight of nine replicated genetic polymorphisms and also four of five suggestive loci are located in or near genes encoding enzymes that are central to the different processes in human lipid metabolism, including beta-oxidation (ACADS, ACADM and ACADL), polyunsaturated fatty acid biosynthesis (FADS1 and ELOVL2), fatty acid synthesis (SCD), breakdown of fats and proteins to energy (ETFDH) and biosynthesis of phospholipids (SPTLC3). Two SNPs are located in or near genes encoding carrier proteins (SLC22A4 and SLC16A9), and two SNPs involve enzymes that are related to amino acid metabolism (PHGDH and CPS1). Only for two genetic variants does the attribution of a metabolic function remain elusive (PLEKHH1 and SYNE2).
Formal Description Interaction-ID: 19489	SNP ACADS rs2014355 affects_quantity of drug/chemical compound Propanoylcarnitine

Comment	Eight of nine replicated genetic polymorphisms and also four of five suggestive loci are located in or near genes encoding enzymes that are central to the different processes in human lipid metabolism, including beta-oxidation (ACADS, ACADM and ACADL), polyunsaturated fatty acid biosynthesis (FADS1 and ELOVL2), fatty acid synthesis (SCD), breakdown of fats and proteins to energy (ETFDH) and biosynthesis of phospholipids (SPTLC3). Two SNPs are located in or near genes encoding carrier proteins (SLC22A4 and SLC16A9), and two SNPs involve enzymes that are related to amino acid metabolism (PHGDH and CPS1). Only for two genetic variants does the attribution of a metabolic function remain elusive (PLEKHH1 and SYNE2).
Formal Description Interaction-ID: 19490	SNP ACADS rs2014355 affects_quantity of drug/chemical compound Butyrylcarnitine

Comment	Eight of nine replicated genetic polymorphisms and also four of five suggestive loci are located in or near genes encoding enzymes that are central to the different processes in human lipid metabolism, including beta-oxidation (ACADS, ACADM and ACADL), polyunsaturated fatty acid biosynthesis (FADS1 and ELOVL2), fatty acid synthesis (SCD), breakdown of fats and proteins to energy (ETFDH) and biosynthesis of phospholipids (SPTLC3). Two SNPs are located in or near genes encoding carrier proteins (SLC22A4 and SLC16A9), and two SNPs involve enzymes that are related to amino acid metabolism (PHGDH and CPS1). Only for two genetic variants does the attribution of a metabolic function remain elusive (PLEKHH1 and SYNE2).
Formal Description Interaction-ID: 19491	SNP ACADM rs211718 affects_quantity of drug/chemical compound Lauroylcarnitine

Comment	Eight of nine replicated genetic polymorphisms and also four of five suggestive loci are located in or near genes encoding enzymes that are central to the different processes in human lipid metabolism, including beta-oxidation (ACADS, ACADM and ACADL), polyunsaturated fatty acid biosynthesis (FADS1 and ELOVL2), fatty acid synthesis (SCD), breakdown of fats and proteins to energy (ETFDH) and biosynthesis of phospholipids (SPTLC3). Two SNPs are located in or near genes encoding carrier proteins (SLC22A4 and SLC16A9), and two SNPs involve enzymes that are related to amino acid metabolism (PHGDH and CPS1). Only for two genetic variants does the attribution of a metabolic function remain elusive (PLEKHH1 and SYNE2).
Formal Description Interaction-ID: 19492	SNP ACADM rs211718 affects_quantity of drug/chemical compound Decanoylcarnitine

Comment	Eight of nine replicated genetic polymorphisms and also four of five suggestive loci are located in or near genes encoding enzymes that are central to the different processes in human lipid metabolism, including beta-oxidation (ACADS, ACADM and ACADL), polyunsaturated fatty acid biosynthesis (FADS1 and ELOVL2), fatty acid synthesis (SCD), breakdown of fats and proteins to energy (ETFDH) and biosynthesis of phospholipids (SPTLC3). Two SNPs are located in or near genes encoding carrier proteins (SLC22A4 and SLC16A9), and two SNPs involve enzymes that are related to amino acid metabolism (PHGDH and CPS1). Only for two genetic variants does the attribution of a metabolic function remain elusive (PLEKHH1 and SYNE2).
Formal Description Interaction-ID: 19493	SNP ACADL rs2286963 affects_quantity of drug/chemical compound Nonanoylcarnitine

Comment	Eight of nine replicated genetic polymorphisms and also four of five suggestive loci are located in or near genes encoding enzymes that are central to the different processes in human lipid metabolism, including beta-oxidation (ACADS, ACADM and ACADL), polyunsaturated fatty acid biosynthesis (FADS1 and ELOVL2), fatty acid synthesis (SCD), breakdown of fats and proteins to energy (ETFDH) and biosynthesis of phospholipids (SPTLC3). Two SNPs are located in or near genes encoding carrier proteins (SLC22A4 and SLC16A9), and two SNPs involve enzymes that are related to amino acid metabolism (PHGDH and CPS1). Only for two genetic variants does the attribution of a metabolic function remain elusive (PLEKHH1 and SYNE2).
Formal Description Interaction-ID: 19494	SNP ACADL rs2286963 affects_quantity of drug/chemical compound Acylcarnitine C10:2

Comment	Eight of nine replicated genetic polymorphisms and also four of five suggestive loci are located in or near genes encoding enzymes that are central to the different processes in human lipid metabolism, including beta-oxidation (ACADS, ACADM and ACADL), polyunsaturated fatty acid biosynthesis (FADS1 and ELOVL2), fatty acid synthesis (SCD), breakdown of fats and proteins to energy (ETFDH) and biosynthesis of phospholipids (SPTLC3). Two SNPs are located in or near genes encoding carrier proteins (SLC22A4 and SLC16A9), and two SNPs involve enzymes that are related to amino acid metabolism (PHGDH and CPS1). Only for two genetic variants does the attribution of a metabolic function remain elusive (PLEKHH1 and SYNE2).
Formal Description Interaction-ID: 19495	SNP ELOVL2 rs9393903 affects_quantity of drug/chemical compound PC aa C40:3

Comment	Eight of nine replicated genetic polymorphisms and also four of five suggestive loci are located in or near genes encoding enzymes that are central to the different processes in human lipid metabolism, including beta-oxidation (ACADS, ACADM and ACADL), polyunsaturated fatty acid biosynthesis (FADS1 and ELOVL2), fatty acid synthesis (SCD), breakdown of fats and proteins to energy (ETFDH) and biosynthesis of phospholipids (SPTLC3). Two SNPs are located in or near genes encoding carrier proteins (SLC22A4 and SLC16A9), and two SNPs involve enzymes that are related to amino acid metabolism (PHGDH and CPS1). Only for two genetic variants does the attribution of a metabolic function remain elusive (PLEKHH1 and SYNE2).
Formal Description Interaction-ID: 19496	SNP ELOVL2 rs9393903 affects_quantity of drug/chemical compound PC aa C42:5

Comment	Eight of nine replicated genetic polymorphisms and also four of five suggestive loci are located in or near genes encoding enzymes that are central to the different processes in human lipid metabolism, including beta-oxidation (ACADS, ACADM and ACADL), polyunsaturated fatty acid biosynthesis (FADS1 and ELOVL2), fatty acid synthesis (SCD), breakdown of fats and proteins to energy (ETFDH) and biosynthesis of phospholipids (SPTLC3). Two SNPs are located in or near genes encoding carrier proteins (SLC22A4 and SLC16A9), and two SNPs involve enzymes that are related to amino acid metabolism (PHGDH and CPS1). Only for two genetic variants does the attribution of a metabolic function remain elusive (PLEKHH1 and SYNE2).
Formal Description Interaction-ID: 19497	SNP CPS1 rs2216405 affects_quantity of drug/chemical compound Glycine
Drugbank entries	Show/Hide entries for
Drugbank DB00145	Glycine not specified GSS
Drugbank DB00145	Glycine not specified GLRA1
Drugbank DB00145	Glycine not specified AGXT
Drugbank DB00145	Glycine not specified GLRB
Drugbank DB00145	Glycine not specified SHMT1
Drugbank DB00145	Glycine not specified GLRA3
Drugbank DB00145	Glycine not specified GLRA2
Drugbank DB00145	Glycine not specified GNMT
Drugbank DB00145	Glycine not specified SHMT2
Drugbank DB00145	Glycine not specified GATM
Drugbank DB00145	Glycine not specified GRIN3B
Drugbank DB00145	Glycine not specified GLDC
Drugbank DB00145	Glycine not specified SLC6A9
Drugbank DB00145	Glycine not specified GCAT
Drugbank DB00145	Glycine not specified ALAS1
Drugbank DB00145	Glycine not specified ALAS2
Drugbank DB00145	Glycine not specified GCSH
Drugbank DB00145	Glycine not specified GARS
Drugbank DB00145	Glycine antagonist GRIN2A
Drugbank DB00145	Glycine not specified BAAT
Drugbank DB00145	Glycine not specified GPR18
Drugbank DB00145	Glycine not specified GRIN2C
Drugbank DB00145	Glycine not specified ""
Drugbank DB00145	Glycine not specified SHMT2
Drugbank DB00145	Glycine not specified DKFZp686P09201
Drugbank DB00145	Glycine not specified GLYAT
Drugbank DB00145	Glycine not specified SLC36A1
Drugbank DB00145	Glycine not specified SHMT2
Drugbank DB00145	Glycine not specified GLYATL2
Drugbank DB00145	Glycine not specified GLYATL1
Drugbank DB00145	Glycine not specified AGXT2
Drugbank DB00145	Glycine not specified SLC32A1
Drugbank DB00145	Glycine not specified PIPOX
Drugbank DB00145	Glycine not specified SLC6A5
Drugbank DB00145	Glycine not specified GCAT
Drugbank DB00145	Glycine not specified ALAS1
Drugbank DB00145	Glycine not specified ALAS2
Drugbank DB00145	Glycine not specified GCSH
Drugbank DB00145	Glycine not specified GARS
Drugbank DB00145	Glycine antagonist GRIN2A
Drugbank DB00145	Glycine not specified BAAT
Drugbank DB00145	Glycine not specified GPR18
Drugbank DB00145	Glycine not specified GSS
Drugbank DB00145	Glycine not specified GRIN2C
Drugbank DB00145	Glycine not specified ""
Drugbank DB00145	Glycine not specified SHMT2
Drugbank DB00145	Glycine not specified DKFZp686P09201
Drugbank DB00145	Glycine not specified GLYAT
Drugbank DB00145	Glycine not specified SLC36A1
Drugbank DB00145	Glycine not specified SHMT2
Drugbank DB00145	Glycine not specified GLYATL2
Drugbank DB00145	Glycine not specified GLYATL1
Drugbank DB00145	Glycine not specified AGXT2
Drugbank DB00145	Glycine not specified SLC32A1
Drugbank DB00145	Glycine not specified PIPOX
Drugbank DB00145	Glycine not specified SLC6A5
Drugbank DB00145	Glycine not specified GRIN3B
Drugbank DB00145	Glycine not specified GLDC
Drugbank DB00145	Glycine not specified SLC6A9
Drugbank DB00145	Glycine not specified GLRA1
Drugbank DB00145	Glycine not specified AGXT
Drugbank DB00145	Glycine not specified GLRB
Drugbank DB00145	Glycine not specified SHMT1
Drugbank DB00145	Glycine not specified GLRA3
Drugbank DB00145	Glycine not specified GLRA2
Drugbank DB00145	Glycine not specified GNMT
Drugbank DB00145	Glycine not specified SHMT2
Drugbank DB00145	Glycine not specified GATM

Comment	Eight of nine replicated genetic polymorphisms and also four of five suggestive loci are located in or near genes encoding enzymes that are central to the different processes in human lipid metabolism, including beta-oxidation (ACADS, ACADM and ACADL), polyunsaturated fatty acid biosynthesis (FADS1 and ELOVL2), fatty acid synthesis (SCD), breakdown of fats and proteins to energy (ETFDH) and biosynthesis of phospholipids (SPTLC3). Two SNPs are located in or near genes encoding carrier proteins (SLC22A4 and SLC16A9), and two SNPs involve enzymes that are related to amino acid metabolism (PHGDH and CPS1). Only for two genetic variants does the attribution of a metabolic function remain elusive (PLEKHH1 and SYNE2).
Formal Description Interaction-ID: 19498	SNP CPS1 rs2216405 affects_quantity of drug/chemical compound PC ae C38:2

Comment	Eight of nine replicated genetic polymorphisms and also four of five suggestive loci are located in or near genes encoding enzymes that are central to the different processes in human lipid metabolism, including beta-oxidation (ACADS, ACADM and ACADL), polyunsaturated fatty acid biosynthesis (FADS1 and ELOVL2), fatty acid synthesis (SCD), breakdown of fats and proteins to energy (ETFDH) and biosynthesis of phospholipids (SPTLC3). Two SNPs are located in or near genes encoding carrier proteins (SLC22A4 and SLC16A9), and two SNPs involve enzymes that are related to amino acid metabolism (PHGDH and CPS1). Only for two genetic variants does the attribution of a metabolic function remain elusive (PLEKHH1 and SYNE2).
Formal Description Interaction-ID: 19499	SNP PLEKHH1 rs7156144 affects_quantity of drug/chemical compound PC ae C32:1

Comment	Eight of nine replicated genetic polymorphisms and also four of five suggestive loci are located in or near genes encoding enzymes that are central to the different processes in human lipid metabolism, including beta-oxidation (ACADS, ACADM and ACADL), polyunsaturated fatty acid biosynthesis (FADS1 and ELOVL2), fatty acid synthesis (SCD), breakdown of fats and proteins to energy (ETFDH) and biosynthesis of phospholipids (SPTLC3). Two SNPs are located in or near genes encoding carrier proteins (SLC22A4 and SLC16A9), and two SNPs involve enzymes that are related to amino acid metabolism (PHGDH and CPS1). Only for two genetic variants does the attribution of a metabolic function remain elusive (PLEKHH1 and SYNE2).
Formal Description Interaction-ID: 19500	SNP PLEKHH1 rs7156144 affects_quantity of drug/chemical compound PC ae C34:1

Comment	Eight of nine replicated genetic polymorphisms and also four of five suggestive loci are located in or near genes encoding enzymes that are central to the different processes in human lipid metabolism, including beta-oxidation (ACADS, ACADM and ACADL), polyunsaturated fatty acid biosynthesis (FADS1 and ELOVL2), fatty acid synthesis (SCD), breakdown of fats and proteins to energy (ETFDH) and biosynthesis of phospholipids (SPTLC3). Two SNPs are located in or near genes encoding carrier proteins (SLC22A4 and SLC16A9), and two SNPs involve enzymes that are related to amino acid metabolism (PHGDH and CPS1). Only for two genetic variants does the attribution of a metabolic function remain elusive (PLEKHH1 and SYNE2).
Formal Description Interaction-ID: 19501	SNP SYNE2 rs11158519 affects_quantity of drug/chemical compound PC ae C38:1

Comment	Eight of nine replicated genetic polymorphisms and also four of five suggestive loci are located in or near genes encoding enzymes that are central to the different processes in human lipid metabolism, including beta-oxidation (ACADS, ACADM and ACADL), polyunsaturated fatty acid biosynthesis (FADS1 and ELOVL2), fatty acid synthesis (SCD), breakdown of fats and proteins to energy (ETFDH) and biosynthesis of phospholipids (SPTLC3). Two SNPs are located in or near genes encoding carrier proteins (SLC22A4 and SLC16A9), and two SNPs involve enzymes that are related to amino acid metabolism (PHGDH and CPS1). Only for two genetic variants does the attribution of a metabolic function remain elusive (PLEKHH1 and SYNE2).
Formal Description Interaction-ID: 19502	SNP SYNE2 rs11158519 affects_quantity of drug/chemical compound PC aa C28:1

Comment	Eight of nine replicated genetic polymorphisms and also four of five suggestive loci are located in or near genes encoding enzymes that are central to the different processes in human lipid metabolism, including beta-oxidation (ACADS, ACADM and ACADL), polyunsaturated fatty acid biosynthesis (FADS1 and ELOVL2), fatty acid synthesis (SCD), breakdown of fats and proteins to energy (ETFDH) and biosynthesis of phospholipids (SPTLC3). Two SNPs are located in or near genes encoding carrier proteins (SLC22A4 and SLC16A9), and two SNPs involve enzymes that are related to amino acid metabolism (PHGDH and CPS1). Only for two genetic variants does the attribution of a metabolic function remain elusive (PLEKHH1 and SYNE2).
Formal Description Interaction-ID: 19503	SNP SPTLC3 rs168622 affects_quantity of drug/chemical compound SM (OH) C24:1

Comment	Eight of nine replicated genetic polymorphisms and also four of five suggestive loci are located in or near genes encoding enzymes that are central to the different processes in human lipid metabolism, including beta-oxidation (ACADS, ACADM and ACADL), polyunsaturated fatty acid biosynthesis (FADS1 and ELOVL2), fatty acid synthesis (SCD), breakdown of fats and proteins to energy (ETFDH) and biosynthesis of phospholipids (SPTLC3). Two SNPs are located in or near genes encoding carrier proteins (SLC22A4 and SLC16A9), and two SNPs involve enzymes that are related to amino acid metabolism (PHGDH and CPS1). Only for two genetic variants does the attribution of a metabolic function remain elusive (PLEKHH1 and SYNE2).
Formal Description Interaction-ID: 19504	SNP SPTLC3 rs168622 affects_quantity of drug/chemical compound SM C16:0

Comment	Eight of nine replicated genetic polymorphisms and also four of five suggestive loci are located in or near genes encoding enzymes that are central to the different processes in human lipid metabolism, including beta-oxidation (ACADS, ACADM and ACADL), polyunsaturated fatty acid biosynthesis (FADS1 and ELOVL2), fatty acid synthesis (SCD), breakdown of fats and proteins to energy (ETFDH) and biosynthesis of phospholipids (SPTLC3). Two SNPs are located in or near genes encoding carrier proteins (SLC22A4 and SLC16A9), and two SNPs involve enzymes that are related to amino acid metabolism (PHGDH and CPS1). Only for two genetic variants does the attribution of a metabolic function remain elusive (PLEKHH1 and SYNE2).
Formal Description Interaction-ID: 19505	SNP ETFDH rs8396 affects_quantity of drug/chemical compound Hydroxytetradecenoylcarnitine

Comment	Eight of nine replicated genetic polymorphisms and also four of five suggestive loci are located in or near genes encoding enzymes that are central to the different processes in human lipid metabolism, including beta-oxidation (ACADS, ACADM and ACADL), polyunsaturated fatty acid biosynthesis (FADS1 and ELOVL2), fatty acid synthesis (SCD), breakdown of fats and proteins to energy (ETFDH) and biosynthesis of phospholipids (SPTLC3). Two SNPs are located in or near genes encoding carrier proteins (SLC22A4 and SLC16A9), and two SNPs involve enzymes that are related to amino acid metabolism (PHGDH and CPS1). Only for two genetic variants does the attribution of a metabolic function remain elusive (PLEKHH1 and SYNE2).
Formal Description Interaction-ID: 19506	SNP ETFDH rs8396 affects_quantity of drug/chemical compound Decanoylcarnitine

Comment	Eight of nine replicated genetic polymorphisms and also four of five suggestive loci are located in or near genes encoding enzymes that are central to the different processes in human lipid metabolism, including beta-oxidation (ACADS, ACADM and ACADL), polyunsaturated fatty acid biosynthesis (FADS1 and ELOVL2), fatty acid synthesis (SCD), breakdown of fats and proteins to energy (ETFDH) and biosynthesis of phospholipids (SPTLC3). Two SNPs are located in or near genes encoding carrier proteins (SLC22A4 and SLC16A9), and two SNPs involve enzymes that are related to amino acid metabolism (PHGDH and CPS1). Only for two genetic variants does the attribution of a metabolic function remain elusive (PLEKHH1 and SYNE2).
Formal Description Interaction-ID: 19507	SNP SLC16A9 rs7094971 affects_quantity of drug/chemical compound Carnitine

Comment	Eight of nine replicated genetic polymorphisms and also four of five suggestive loci are located in or near genes encoding enzymes that are central to the different processes in human lipid metabolism, including beta-oxidation (ACADS, ACADM and ACADL), polyunsaturated fatty acid biosynthesis (FADS1 and ELOVL2), fatty acid synthesis (SCD), breakdown of fats and proteins to energy (ETFDH) and biosynthesis of phospholipids (SPTLC3). Two SNPs are located in or near genes encoding carrier proteins (SLC22A4 and SLC16A9), and two SNPs involve enzymes that are related to amino acid metabolism (PHGDH and CPS1). Only for two genetic variants does the attribution of a metabolic function remain elusive (PLEKHH1 and SYNE2).
Formal Description Interaction-ID: 19509	SNP ACSL1 rs2046813 affects_quantity of drug/chemical compound PC ae C44:5

Comment	Eight of nine replicated genetic polymorphisms and also four of five suggestive loci are located in or near genes encoding enzymes that are central to the different processes in human lipid metabolism, including beta-oxidation (ACADS, ACADM and ACADL), polyunsaturated fatty acid biosynthesis (FADS1 and ELOVL2), fatty acid synthesis (SCD), breakdown of fats and proteins to energy (ETFDH) and biosynthesis of phospholipids (SPTLC3). Two SNPs are located in or near genes encoding carrier proteins (SLC22A4 and SLC16A9), and two SNPs involve enzymes that are related to amino acid metabolism (PHGDH and CPS1). Only for two genetic variants does the attribution of a metabolic function remain elusive (PLEKHH1 and SYNE2).
Formal Description Interaction-ID: 19525	SNP ACSL1 rs2046813 affects_quantity of drug/chemical compound PC ae C42:5

Comment	Eight of nine replicated genetic polymorphisms and also four of five suggestive loci are located in or near genes encoding enzymes that are central to the different processes in human lipid metabolism, including beta-oxidation (ACADS, ACADM and ACADL), polyunsaturated fatty acid biosynthesis (FADS1 and ELOVL2), fatty acid synthesis (SCD), breakdown of fats and proteins to energy (ETFDH) and biosynthesis of phospholipids (SPTLC3). Two SNPs are located in or near genes encoding carrier proteins (SLC22A4 and SLC16A9), and two SNPs involve enzymes that are related to amino acid metabolism (PHGDH and CPS1). Only for two genetic variants does the attribution of a metabolic function remain elusive (PLEKHH1 and SYNE2).
Formal Description Interaction-ID: 19527	SNP SCD rs603424 affects_quantity of drug/chemical compound Tetradecanoylcarnitine

Comment	Eight of nine replicated genetic polymorphisms and also four of five suggestive loci are located in or near genes encoding enzymes that are central to the different processes in human lipid metabolism, including beta-oxidation (ACADS, ACADM and ACADL), polyunsaturated fatty acid biosynthesis (FADS1 and ELOVL2), fatty acid synthesis (SCD), breakdown of fats and proteins to energy (ETFDH) and biosynthesis of phospholipids (SPTLC3). Two SNPs are located in or near genes encoding carrier proteins (SLC22A4 and SLC16A9), and two SNPs involve enzymes that are related to amino acid metabolism (PHGDH and CPS1). Only for two genetic variants does the attribution of a metabolic function remain elusive (PLEKHH1 and SYNE2).
Formal Description Interaction-ID: 19528	SNP SCD rs603424 affects_quantity of drug/chemical compound Acylcarnitine C16:1

Comment	Eight of nine replicated genetic polymorphisms and also four of five suggestive loci are located in or near genes encoding enzymes that are central to the different processes in human lipid metabolism, including beta-oxidation (ACADS, ACADM and ACADL), polyunsaturated fatty acid biosynthesis (FADS1 and ELOVL2), fatty acid synthesis (SCD), breakdown of fats and proteins to energy (ETFDH) and biosynthesis of phospholipids (SPTLC3). Two SNPs are located in or near genes encoding carrier proteins (SLC22A4 and SLC16A9), and two SNPs involve enzymes that are related to amino acid metabolism (PHGDH and CPS1). Only for two genetic variants does the attribution of a metabolic function remain elusive (PLEKHH1 and SYNE2).
Formal Description Interaction-ID: 19529	SNP SLC22A4 rs272889 affects_quantity of drug/chemical compound Valine

Comment	Eight of nine replicated genetic polymorphisms and also four of five suggestive loci are located in or near genes encoding enzymes that are central to the different processes in human lipid metabolism, including beta-oxidation (ACADS, ACADM and ACADL), polyunsaturated fatty acid biosynthesis (FADS1 and ELOVL2), fatty acid synthesis (SCD), breakdown of fats and proteins to energy (ETFDH) and biosynthesis of phospholipids (SPTLC3). Two SNPs are located in or near genes encoding carrier proteins (SLC22A4 and SLC16A9), and two SNPs involve enzymes that are related to amino acid metabolism (PHGDH and CPS1). Only for two genetic variants does the attribution of a metabolic function remain elusive (PLEKHH1 and SYNE2).
Formal Description Interaction-ID: 19530	SNP SLC22A4 rs272889 affects_quantity of drug/chemical compound Valerylcarnitine

Comment	Eight of nine replicated genetic polymorphisms and also four of five suggestive loci are located in or near genes encoding enzymes that are central to the different processes in human lipid metabolism, including beta-oxidation (ACADS, ACADM and ACADL), polyunsaturated fatty acid biosynthesis (FADS1 and ELOVL2), fatty acid synthesis (SCD), breakdown of fats and proteins to energy (ETFDH) and biosynthesis of phospholipids (SPTLC3). Two SNPs are located in or near genes encoding carrier proteins (SLC22A4 and SLC16A9), and two SNPs involve enzymes that are related to amino acid metabolism (PHGDH and CPS1). Only for two genetic variants does the attribution of a metabolic function remain elusive (PLEKHH1 and SYNE2).
Formal Description Interaction-ID: 19531	SNP PHGDH rs541503 affects_quantity of drug/chemical compound Ornithine

Comment	Eight of nine replicated genetic polymorphisms and also four of five suggestive loci are located in or near genes encoding enzymes that are central to the different processes in human lipid metabolism, including beta-oxidation (ACADS, ACADM and ACADL), polyunsaturated fatty acid biosynthesis (FADS1 and ELOVL2), fatty acid synthesis (SCD), breakdown of fats and proteins to energy (ETFDH) and biosynthesis of phospholipids (SPTLC3). Two SNPs are located in or near genes encoding carrier proteins (SLC22A4 and SLC16A9), and two SNPs involve enzymes that are related to amino acid metabolism (PHGDH and CPS1). Only for two genetic variants does the attribution of a metabolic function remain elusive (PLEKHH1 and SYNE2).
Formal Description Interaction-ID: 19532	SNP PHGDH rs541503 affects_quantity of drug/chemical compound Serine