General Information:

Id: 1,847 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Homo sapiens
article
Reference: Cho DH et al.(2009) S-nitrosylation of Drp1 mediates beta-amyloid-related mitochondrial fission and neuronal injury. Science 324: 102-105 [PMID: 19342591]

Interaction Information:

Comment NO induces dimer formation of Drp1 via S-nitrosylation of Cys644 and influence its GTPase activity.
Formal Description
Interaction-ID: 14003

drug/chemical compound

NO

increases_activity of

process

DRP1 homodimerization

of DRP1 via S-nitrosylation of Cys644