General Information:

Id: 1,847
Diseases: Alzheimer disease - [OMIM]
Homo sapiens
article
Reference: Cho DH et al.(2009) S-nitrosylation of Drp1 mediates beta-amyloid-related mitochondrial fission and neuronal injury. Science 324: 102-105 [PMID: 19342591]

Interaction Information:

Comment Nitric oxide is produced in response to amyloid beta protein.
Formal Description
Interaction-ID: 13991

gene/protein

Amyloid beta peptide

affects_quantity of

drug/chemical compound

NO

Comment Endogenous Drp1 was S-nitrosylated by endogenous NO.
Formal Description
Interaction-ID: 13993

drug/chemical compound

NO

affects_processing of

gene/protein

DNM1L

S-nitrosylation of endogenous DRP1/DNM1L
Comment SNO-Drp1 is increased in brains of human Alzheimer's disease patients and may thus contribute to the pathogenesis of neurodegeneration.
Formal Description
Interaction-ID: 13999

disease

Alzheimer disease

increases_quantity of

protein modification

DNM1L-SNO

in AD brain; S-nitrosylated DRP1
Comment NO induces mitochondrial fission.
Formal Description
Interaction-ID: 14000

drug/chemical compound

NO

increases_activity of

process

mitochondrial fission

Comment NO induces dimer formation of Drp1 via S-nitrosylation of Cys644 and influence its GTPase activity.
Formal Description
Interaction-ID: 14003

drug/chemical compound

NO

increases_activity of

process

DRP1 homodimerization

of DRP1 via S-nitrosylation of Cys644
Comment NO induces dimer formation of Drp1 via S-nitrosylation of Cys644 and influence its GTPase activity.
Formal Description
Interaction-ID: 14006

drug/chemical compound

NO

increases_quantity of

protein modification

DNM1L-SNO (homodimer)

homodimer formation
Comment NO influences the GTPase activity of DRP1/DNM1L.
Formal Description
Interaction-ID: 14009

drug/chemical compound

NO

affects_activity of

gene/protein

GTPase

of DRP1-SNO via DRP1-SNO dimerization
Comment NO induces dimer formation of Drp1 via S-nitrosylation of Cys644 and influence its GTPase activity.
Formal Description
Interaction-ID: 14010

process

DRP1 homodimerization

affects_activity of

protein modification

DNM1L-SNO

Comment NO induces dimer formation of Drp1 via S-nitrosylation of Cys644 and influence its GTPase activity.
Formal Description
Interaction-ID: 14012

process

DRP1 homodimerization

affects_activity of

gene/protein

GTPase

of DRP1-SNO
Comment NO induces dimer formation of Drp1 via S-nitrosylation of Cys644 and influence its GTPase activity.
Formal Description
Interaction-ID: 14015

protein modification

DNM1L-SNO (homodimer)

affects_activity of

gene/protein

GTPase