General Information:

Id: 14,021 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Metabolic
Rattus norvegicus
female
90 young or middle-aged female Sprague-Dawley rats, a rat model recapitulating fundamental characteristics of the human perimenopause
article/cited
Reference: Yin F et al.(2015) The perimenopausal aging transition in the female rat brain: decline in bioenergetic systems and synaptic plasticity Neurobiol Aging 36: 2282-2295 [PMID: 25921624]

Interaction Information:

Comment The 9‚Äď10 month regular cyclers (compared to 6-month cyclers) showed a significant decline in the expression of genes involved in molecule transport (heat shock 60 kDa protein 1 (HSPD1) and Bcl2/adenovirus E1B interacting protein 1 (Bnip1)); mitochondrial redox enzymes glutaredoxin 2 (Glrx2) and peroxiredoxin 3 (Prx3); the glutamate decarboxylases (Gad1 and Gad2, which generate the neurotransmitter GABA), and a neuronal survival gene (chemokine receptor Cxrcr4).
Formal Description
Interaction-ID: 132537

gene/protein

GAD2

increases_quantity of

drug/chemical compound

GABA

Drugbank entries Show/Hide entries for GAD2