General Information:

Id: 1,397 (click here to show other Interactions for entry)
Diseases: Parkinson disease
Mus musculus
BTO:0000142 brain; BTO:0003945 MN-9D cell
article
Reference: Perez RG et al.(2002) A role for alpha-synuclein in the regulation of dopamine biosynthesis J. Neurosci. 22: 3090-3099 [PMID: 11943812]

Interaction Information:

Comment Overexpression of wild-type or A53T mutant alpha-synuclein did not significantly alter tyrosine hydroxylase protein levels in our stably transfected cells. However, overexpressing cell lines had significantly reduced tyrosine hydroxylase activity and a corresponding reduction in dopamine synthesis.
Formal Description
Interaction-ID: 9668

gene/protein

SNCA

decreases_quantity of

drug/chemical compound

Dopamine

via reduction of TH activity
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